{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:05Z","timestamp":1786978085862,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Morphology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to assess the impact of occlusal loading on secondary tooth eruption and to determine the extent to which altering the occlusal loading influences the magnitude of secondary eruption through an experimental rat model. The present sample consisted of 48 male Wistar rats. At the onset of the experiment, 24 rats were 4 weeks old (young rats) and 24 rats were 26 weeks old (adult). Within each age group, the rats were further divided into two equal subgroups (12 rats each), receiving either a soft\u2010 or hard\u2010food diet for the 3\u2010month duration of the experiment. The primary outcome was the tooth position changes relative to stable references in the coronal plane by evaluating the distance between the mandibular first molars and the inferior alveolar canal. Microcomputed tomography scans were taken from all rats at three standardized intervals over the 3\u2010month study period. Descriptive statistics were calculated by age and diet over time, and the evolution of the outcomes were plotted by age and diet over time. Longitudinal data analysis via generalized estimating equations was performed to examine the effect of age, diet and time on the primary outcomes. Secondary tooth eruption was observed in all age groups (young and adult) regardless of diet consistency (soft or hard food). In young rats, the secondary eruption was greater in the animals fed a soft diet than those fed a hard diet. In adult rats, minimal difference in secondary tooth eruption were found between different diet consistencies. Occlusal loading influences secondary tooth eruption in teeth with an established occlusal contact. The quantity of eruption in growing rats is higher when occlusal loading is less, providing a certain amount of secondary tooth eruption occurs. This difference, however, is not evident in adult rats, at least during the given 3\u2010month time frame.<\/jats:p>","DOI":"10.1002\/jmor.21755","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T02:05:10Z","timestamp":1722477910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of occlusal loading on secondary tooth eruption: An experimental study using a rat model"],"prefix":"10.1002","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-5207","authenticated-orcid":false,"given":"Ourania","family":"Stergiopulos","sequence":"first","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine, University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Lagou","sequence":"additional","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine, University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Antonarakis","sequence":"additional","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine, University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pandis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Kiliaridis","sequence":"additional","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine, University of Geneva Geneva Switzerland"},{"name":"Department of Orthodontics and Dentofacial Orthopedics University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"53","article-title":"Vertical relapse after orthodontic and orthognathic surgical treatment in a patient with myotonic dystrophy","volume":"20","author":"Antonarakis G. 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