{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:53:04Z","timestamp":1772999584413,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Morphology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lizards represent the closest amniotes to mammals able to regenerate many tissues, therefore are useful models for studies of mammalian regeneration. Tail regeneration occurs by stem cells but tissue dedifferentiation may also be involved. When injury damages numerous tissues they may undergo dedifferentiation (re\u2010programming). This was indicated especially in muscles and connectives of the tail 7\u201310 days postamputation. The transcriptome of regenerating tail and limb from the lizard\n                    <jats:italic>Podarcis muralis<\/jats:italic>\n                    detected upregulation of spalt\u2010like genes (sall 1\u20134), known to be involved in re\u2010programming. Here, immunolocalization of the sall4 protein and 5BrdU\u2010labeled cells (proliferating) was conducted. A variable number of 5BrdU and sall4\u2010positive cells are detected among stump connective tissues, injured muscles, and dermis. Labeling for sall4 is cytoplasmic and also nuclear, and it is also noted in cytoplasmic muscle fragments. The latter likely derived from the fragmentation of injured muscles in both tail and limb stumps at 7\u201316 days postamputation. Occasional, isolated sall4\u2010labeled cells are rarely detected in the blastema, and none in the wound epidermis or regenerating spinal cord and muscles. The present study indicates that cell dedifferentiation occurs during early stages of tail and limb amputation in lizards, contributing with activated stem cells to their regeneration or scarring.\n                  <\/jats:p>","DOI":"10.1002\/jmor.70091","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:38:41Z","timestamp":1759217921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sall Genes and Proteins Activation during Early Tail and Limb Regeneration in the Lizard\n                    <i>Podarcis muralis<\/i>\n                    Suggests Dedifferentiation"],"prefix":"10.1002","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-2217","authenticated-orcid":false,"given":"Alibardi","family":"Lorenzo","sequence":"first","affiliation":[{"name":"Comparative Histolab Padova Veneto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01379-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-6395.2009.00409.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22581"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2016.03.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.22754"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/azo.12161"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20838"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jez.b.22835","article-title":"Perspective: Appendages Regeneration in Amphibians and Some Reptiles Derived from Specific Evolutionary Histories","volume":"330","author":"Alibardi L.","year":"2019","journal-title":"Journal of Experimental Zoology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/azo.12255"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.22901"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2021.151844"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246292"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-6395.2009.00432.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090890404"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091610411"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091610411"},{"key":"e_1_2_9_18_1","first-page":"244","article-title":"Istogenesi e Morfogenesi dei Muscoli Nella Rigenerazione Della Coda di Lucertola in Seguito a Mutilazione Spontanea","volume":"57","author":"Brunetti P. 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