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The terpolymer is composed of poly(3\u2010sulfopropyl methacrylate), as the hydrophilic component, poly(<jats:italic>n<\/jats:italic>\u2010dodecyl acrylate), as the hydrophobic component and poly(barbiturate receptor), as the component for drug recognition. The combined approach was tested on four model compounds from the family of barbiturates, phenobarbital, mephobarbital, secobarbital, and thiopental, chosen based on their differential hydrogen bonding capabilities. Drug encapsulation and hydrogen\u2010bonding based recognition within the micellar core of the receptor\u2013terpolymer was demonstrated by micellar electrokinetic chromatography. The resulting trends in the binding affinity of the barbiturates to the receptor\u2013terpolymer, were correlated to the trends obtained from computational docking simulations. This receptor\u2010modified polymeric micelle is intended to serve as a model for the design of novel, versatile, and highly selective molecular scaffolds that will provide suitable environment for host\u2013guest chemistry and act as simplified mimics to more complex biological systems. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jmr.1098","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T06:49:23Z","timestamp":1305614963000},"page":"678-686","source":"Crossref","is-referenced-by-count":6,"title":["Receptor\u2010attached amphiphilic terpolymer for selective drug recognition in aqueous solutions"],"prefix":"10.1002","volume":"24","author":[{"given":"Eriketi 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