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Bifunctional DNA glycosylases also possess associated apurinic\/apyrimidinic (AP) lyase activity that nick the damaged DNA strand at an abasic (or AP) site, formed either spontaneously or at the first step of repair. NEIL1 is a bifunctional DNA glycosylase capable of processing lesions, including AP sites, not only in double\u2010stranded but also in single\u2010stranded DNA. Here, we show that proteins participating in DNA damage response, YB\u20101 and RPA, affect AP site cleavage by NEIL1. Stimulation of the AP lyase activity of NEIL1 was observed when an AP site was located in a 60\u2009nt\u2010long double\u2010stranded DNA. Both RPA and YB\u20101 inhibited AP site cleavage by NEIL1 when the AP site was located in single\u2010stranded DNA. Taking into account a direct interaction of YB\u20101 with the AP site, located in single\u2010stranded DNA, and the high affinity of both YB\u20101 and RPA for single\u2010stranded DNA, this behavior is presumably a consequence of a competition with NEIL1 for the DNA substrate. Xeroderma pigmentosum complementation group C protein (XPC), a key protein of another DNA repair pathway, was shown to interact directly with AP sites but had no effect on AP site cleavage by NEIL1. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jmr.2182","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T10:44:55Z","timestamp":1332845095000},"page":"224-233","source":"Crossref","is-referenced-by-count":20,"title":["Effect of the multifunctional proteins RPA, YB\u20101, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1"],"prefix":"10.1002","volume":"25","author":[{"given":"Pavel","family":"Pestryakov","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine Siberian Division of Russian Academy of Sciences  Prospect Lavrentieva 8 Novosibirsk 630090 Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry O.","family":"Zharkov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine Siberian Division of Russian Academy of Sciences  Prospect Lavrentieva 8 Novosibirsk 630090 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