{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:49:37Z","timestamp":1723182577700},"reference-count":68,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T00:00:00Z","timestamp":1340668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1\u2013IgG4) from patients with viral (tick\u2010borne encephalitis), bacterial infections (streptococcal infection or erysipelas), and suppurative surgical infections caused by epidermal staphylococci as well as from patients with autoimmune diseases (systemic lupus erythematosus and multiple sclerosis) are catalytically active in the hydrolysis of supercoiled DNA. The hydrolysis of DNA was analyzed by agarose gel electrophoresis. The catalytic activities of nonfractionated IgGs increased in the following order: tick\u2010borne encephalitis\u2009&lt;\u2009suppurative surgical infection\u2009&lt;\u2009streptococcal infection\u2009&lt;\u2009multiple sclerosis\u2009&lt;\u2009systemic lupus erythematosus, whereas IgGs of healthy donors were inactive. However, the pools of antibodies corresponding to any particular disease were characterized by a specific ratio of IgGs of all four subclasses (IgG1\u2013IgG4) and IgGs containing \u03bb\u2010 and \u03ba\u2010type light chains, and each of these subfractions of immunoglobulins demonstrated characteristic relative DNase activity. The relative activities of IgGs containing \u03bb\u2010type light chains may on average be higher, lower, or comparable with those for IgGs with \u03ba\u2010type light chains. The relative contributions of IgGs of different subclasses to the total activity of IgGs also varied widely in the case of various diseases: IgG1 (7%\u201345%), IgG2 (0.4%\u201373%), IgG3 (0%\u201312%), and IgG4 (9%\u201366%). Thus, immune systems of patients with different diseases can generate a variety of anti\u2010DNA abzymes of different types and with different catalytic properties, which can play an important role in the pathogenesis or protection from the development of these diseases. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jmr.2185","type":"journal-article","created":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T16:50:07Z","timestamp":1340729407000},"page":"383-392","source":"Crossref","is-referenced-by-count":2,"title":["IgGs containing \u03bb\u2010 and \u03ba\u2010type light chains and of all subclasses (IgG1\u2013IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA"],"prefix":"10.1002","volume":"25","author":[{"given":"Taisiya A.","family":"Parkhomenko","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine Siberian Division of Russian Academy of Sciences  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina N.","family":"Buneva","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine Siberian Division of Russian Academy of Sciences  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris M.","family":"Doronin","sequence":"additional","affiliation":[{"name":"Novosibirsk Medical University Ministry of Public Health of the Russian Federation  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita V.","family":"Volkova","sequence":"additional","affiliation":[{"name":"Vitebsk State Medical University  Belarus Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey A.","family":"Senkovich","sequence":"additional","affiliation":[{"name":"Vitebsk State Medical University  Belarus Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor I.","family":"Generalov","sequence":"additional","affiliation":[{"name":"Vitebsk State Medical University  Belarus Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgy A.","family":"Nevinsky","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine Siberian Division of Russian Academy of Sciences  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"460","article-title":"Catalytic heterogeneity of polyclonal RNA\u2010hydrolyzing IgM from sera of patients with lupus erythematosus","volume":"6","author":"Andrievskaya OA","year":"2000","journal-title":"Med. 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