{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:44:42Z","timestamp":1771368282167,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DST, India","award":["SB\/S1\/PC-011\/2013"],"award-info":[{"award-number":["SB\/S1\/PC-011\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Electron transfer (ET) reactions are important for their implications in both oxidative and reductive DNA damages. The current contribution investigates the efficacy of caffeine, a xanthine alkaloid in preventing UVA radiation induced ET from a carcinogen, benzo[a]pyrene (BP) to DNA by forming stable caffeine\u2013BP complexes. While steady\u2010state emission and absorption results emphasize the role of caffeine in hosting BP in aqueous medium, the molecular modeling studies propose the energetically favorable structure of caffeine\u2013BP complex. The picosecond\u2010resolved emission spectroscopic studies precisely explore the caffeine\u2010mediated inhibition of ET from BP to DNA under UVA radiation. The potential therapeutic activity of caffeine in preventing DNA damage has been ensured by agarose gel electrophoresis. Furthermore, time\u2010gated fluorescence microscopy has been used to monitor caffeine\u2010mediated exclusion of BP from various cell lines including squamous epithelial cells, WI\u201038 (fibroblast), MCF\u20107 (breast cancer) and HeLa (cervical cancer) cells. Our<jats:italic>in vitro<\/jats:italic>and<jats:italic>ex vivo<\/jats:italic>experimental results provide imperative evidences about the role of caffeine in modified biomolecular recognition of a model carcinogen BP by DNA resulting dissociation of the carcinogen from various cell lines, implicating its potential medicinal applications in the prevention of other toxic organic molecule induced cellular damages. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jmr.2379","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T10:09:32Z","timestamp":1401444572000},"page":"510-520","source":"Crossref","is-referenced-by-count":5,"title":["Role of caffeine in DNA recognition of a potential food\u2010carcinogen benzo[a]pyrene and UVA induced DNA damage"],"prefix":"10.1002","volume":"27","author":[{"given":"Soma","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Chemical, Biological &amp; Macromolecular Sciences S. N. Bose National Centre for Basic Sciences Block JD, Sector III Salt Lake Kolkata 700 098 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhi","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological &amp; Macromolecular Sciences S. N. 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