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The experiments were performed at neutral pH (7.4) and acid pH (5.3) conditions. The data obtained confirm the role of LBP as a cell receptor for two typical viral species of the <jats:italic>Flavivirus<\/jats:italic> genus. A comparison of these data with similar data obtained for another cell receptor of this family, namely human \u03b1V\u03b23 integrin, reveals that both these receptors are very important. Studying the specific interaction between the cell receptors in question and specially prepared monoclonal antibodies against them, we could show that both interaction sites involved in the process of virus\u2013cell interaction remain intact at pH 5.3. At the same time, for these acid conditions characteristic for an endosome during flavivirus\u2013cell membrane fusion, SMDFS data reveal the existence of a force\u2010induced (effective already for forces as small as 30\u201370\u2009pN) sharp globule\u2013coil transition for LBP and LBP\u2013fragments of protein E complexes. We argue that this conformational transformation, being an analog of abrupt first\u2010order phase transition and having similarity with the famous Rayleigh hydrodynamic instability, might be indispensable for the flavivirus\u2013cell membrane fusion process. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jmr.2399","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T05:26:53Z","timestamp":1413437213000},"page":"727-738","source":"Crossref","is-referenced-by-count":16,"title":["Force\u2010induced globule\u2013coil transition in laminin binding protein and its role for viral\u2013cell membrane fusion"],"prefix":"10.1002","volume":"27","author":[{"given":"Boris N.","family":"Zaitsev","sequence":"first","affiliation":[{"name":"Department of Molecular Virology for Flaviviruses and Viral Hepatitis State Research Center for Virology and Biotechnology \u201cVector\u201d  Koltsovo Novosibirsk region 630559 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Laboratoire de Physique de la Mati\u00e8re Vivante IPMC, BSP, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  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