{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:57Z","timestamp":1788872337623,"version":"build-2803163510"},"reference-count":113,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":167,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Instituto de Ciencia y Tecnolog\u00eda del DF","award":["PIRIVE09-9"],"award-info":[{"award-number":["PIRIVE09-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mol. Recognit."],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1002\/jmr.2470","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T14:08:25Z","timestamp":1426687705000},"page":"553-564","source":"Crossref","is-referenced-by-count":6,"title":["A continuous peptide epitope reacting with pandemic influenza AH1N1 predicted by bioinformatic approaches"],"prefix":"10.1002","volume":"28","author":[{"given":"Jonathan P.","family":"Carrillo-Vazquez","sequence":"first","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Biof\u00edsica Computacional; Doctorado en Biotecnolog\u00eda ENMH-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Correa-Basurto","sequence":"additional","affiliation":[{"name":"Laboratorio de Modelado Molecular y Dise\u00f1o de F\u00e1rmacos; Escuela Superior de Medicina-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazmin","family":"Garc\u00eda-Machorro","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n; Escuela Superior de Medicina-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Campos-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Molecular; Escuela Superior de Medicina-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Moreau","sequence":"additional","affiliation":[{"name":"CNRS FRE 3009, SysDiag; CAP DELTA; Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Rosas-Trigueros","sequence":"additional","affiliation":[{"name":"Laboratorio Transdisciplinario de Investigaci\u00f3n en Sistemas Evolutivos SEPI-ESCOM-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar A.","family":"Reyes-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Biof\u00edsica Computacional; Doctorado en Biotecnolog\u00eda ENMH-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon","family":"Rojas-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Biotecnolog\u00eda Aplicada-IPN; Tlaxcala Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Absalom","family":"Zamorano-Carrillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Biof\u00edsica Computacional; Doctorado en Biotecnolog\u00eda ENMH-IPN; Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"10.1002\/jmr.2470-BIB0001|jmr2470-cit-0001","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3201\/eid0505.990507","article-title":"The economic impact of pandemic influenza in the United States: priorities for intervention","volume":"5","author":"Meltzer","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmr.2470-BIB0002|jmr2470-cit-0002","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1473-3099(05)70270-X","article-title":"Understanding the symptoms of the common cold and influenza","volume":"5","author":"Eccles","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1002\/jmr.2470-BIB0003|jmr2470-cit-0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/515616","article-title":"Pandemic versus epidemic influenza mortality: a pattern of changing age distribution","volume":"178","author":"Simonsen","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1002\/jmr.2470-BIB0004|jmr2470-cit-0004","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.genet.36.052402.152757","article-title":"Genetics of influenza viruses","volume":"36","author":"Steinhauer","year":"2002","journal-title":"Annu Rev Genet"},{"key":"10.1002\/jmr.2470-BIB0005|jmr2470-cit-0005","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1098\/rstb.2001.0981","article-title":"Developing vaccines against pandemic influenza","volume":"29","author":"Wood","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1002\/jmr.2470-BIB0006|jmr2470-cit-0006","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.312.5772.380","article-title":"A one-size-fits-all flu vaccine?","volume":"5772","author":"Kaiser","year":"2006","journal-title":"Science"},{"key":"10.1002\/jmr.2470-BIB0007|jmr2470-cit-0007","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000053869","article-title":"A candidate vaccine against influenza virus intensively improved the immunogenicity of a neutralizing epitope","volume":"127","author":"Lu","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1002\/jmr.2470-BIB0008|jmr2470-cit-0008","doi-asserted-by":"crossref","first-page":"127152","DOI":"10.1073\/pnas.1132114100","article-title":"Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus","volume":"100","author":"Plotkin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jmr.2470-BIB0009|jmr2470-cit-0009","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1002\/jmr.2470-BIB0010|jmr2470-cit-0010","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.83.2.226","article-title":"Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains)","volume":"83","author":"Novotn\u00fd","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jmr.2470-BIB0011|jmr2470-cit-0011","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.vaccine.2004.05.028","article-title":"High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity","volume":"23","author":"Liu","year":"2004","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0012|jmr2470-cit-0012","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.intimp.2004.12.005","article-title":"The epitope recognized by a monoclonal antibody in influenza A virus M2 protein is immunogenic and confers immune protection","volume":"5","author":"Zou","year":"2005","journal-title":"Int Immunopharmacol"},{"key":"10.1002\/jmr.2470-BIB0013|jmr2470-cit-0013","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.1176225","article-title":"Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans","volume":"325","author":"Garten","year":"2009","journal-title":"Science"},{"key":"10.1002\/jmr.2470-BIB0014|jmr2470-cit-0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1743-422X-6-69","article-title":"Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses","volume":"6","author":"Goh","year":"2009","journal-title":"Virol J"},{"issue":"11","key":"10.1002\/jmr.2470-BIB0015|jmr2470-cit-0015","doi-asserted-by":"crossref","first-page":"e1190","DOI":"10.1371\/journal.pone.0001190","article-title":"Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets","volume":"2","author":"Heiny","year":"2007","journal-title":"PLoS One"},{"key":"10.1002\/jmr.2470-BIB0016|jmr2470-cit-0016","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1073\/pnas.0701396104","article-title":"Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution","volume":"104","author":"Shih","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jmr.2470-BIB0017|jmr2470-cit-0017","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/bbrc.2000.2384","article-title":"Mapping of a protective helper T cell epitope of human influenza A virus hemagglutinin","volume":"270","author":"Gogol\u00e1k","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jmr.2470-BIB0018|jmr2470-cit-0018","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0092-8674(82)90135-0","article-title":"The antigenic structure of the influenza virus A\/PR\/8\/34 hemagglutinin (H1 subtype)","volume":"31","author":"Caton","year":"1982","journal-title":"Cell"},{"key":"10.1002\/jmr.2470-BIB0019|jmr2470-cit-0019","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.4049\/jimmunol.163.12.6424","article-title":"Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands","volume":"163","author":"Wilson","year":"1999","journal-title":"J Immunol"},{"issue":"9","key":"10.1002\/jmr.2470-BIB0020|jmr2470-cit-0020","doi-asserted-by":"crossref","first-page":"e1295","DOI":"10.1371\/journal.pntd.0001295","article-title":"In silico analysis of six known Leishmania major antigens and in vitro evaluation of specific epitopes eliciting HLA-A2 restricted CD8 T cell response","volume":"5","author":"Seyed","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1002\/jmr.2470-BIB0021|jmr2470-cit-0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1389450043490668","article-title":"Epitope identification and discovery using phage display libraries: applications in vaccine development and diagnostics","volume":"5","author":"Wang","year":"2004","journal-title":"Curr Drug Targets"},{"key":"10.1002\/jmr.2470-BIB0022|jmr2470-cit-0022","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1128\/JVI.00196-14","article-title":"Specificities of human CD4+ T cell responses to an inactivated Flavivirus vaccine and infection: correlation with structure and epitope prediction","volume":"88","author":"Schwaiger","year":"2014","journal-title":"J Virol"},{"key":"10.1002\/jmr.2470-BIB0023|jmr2470-cit-0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12250-011-3159-4","article-title":"Advances of bioinformatics tools applied in virus epitopes prediction","volume":"26","author":"Chen","year":"2011","journal-title":"Virol Sin"},{"key":"10.1002\/jmr.2470-BIB0024|jmr2470-cit-0024","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1471-2105-9-71","article-title":"PEPOP: computational design of immunogenic peptides","volume":"9","author":"Moreau","year":"2008","journal-title":"BMC Bioinf"},{"key":"10.1002\/jmr.2470-BIB0025|jmr2470-cit-0025","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11434-009-0429-3","article-title":"Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus","volume":"54","author":"Wu","year":"2009","journal-title":"Chin Sci Bull"},{"key":"10.1002\/jmr.2470-BIB0026|jmr2470-cit-0026","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1673-8527(08)60117-4","article-title":"BiodMHC: an online server for the prediction of MHC class II-peptide binding affinity","volume":"36","author":"Wang","year":"2009","journal-title":"J Genet Genomics"},{"key":"10.1002\/jmr.2470-BIB0027|jmr2470-cit-0027","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-60327-118-9_14","article-title":"Application of machine learning techniques in predicting MHC binders","volume":"409","author":"Lata","year":"2007","journal-title":"Methods Mol Biol"},{"key":"10.1002\/jmr.2470-BIB0028|jmr2470-cit-0028","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPred: prediction of HLA-DR binding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1002\/jmr.2470-BIB0029|jmr2470-cit-0029","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.chembiol.2013.10.002","article-title":"Finding epitopes with computers","volume":"20","author":"Malito","year":"2013","journal-title":"Chem Biol"},{"key":"10.1002\/jmr.2470-BIB0030|jmr2470-cit-0030","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fimmu.2013.00268","article-title":"Structure-based, rational design of T cell receptors","volume":"4","author":"Zoete","year":"2013","journal-title":"Front Immunol"},{"key":"10.1002\/jmr.2470-BIB0031|jmr2470-cit-0031","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.str.2014.02.003","article-title":"Using a combined computational-experimental approach to predict antibody-specific B cell epitopes","volume":"22","author":"Sela-Culang","year":"2014","journal-title":"Structure"},{"key":"10.1002\/jmr.2470-BIB0032|jmr2470-cit-0032","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jim.2013.02.006","article-title":"Predictor for the effect of amino acid composition on CD4+ T cell epitopes preprocessing","volume":"391","author":"Hoze","year":"2013","journal-title":"J Immunol Methods"},{"key":"10.1002\/jmr.2470-BIB0033|jmr2470-cit-0033","first-page":"33","article-title":"Synthetic peptide vaccines and the search for neutralization B cell epitopes","volume":"2","author":"Van Regenmortel","year":"2009","journal-title":"The Open Vaccine Journal"},{"key":"10.1002\/jmr.2470-BIB0034|jmr2470-cit-0034","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jmr.2394","article-title":"Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition","volume":"27","author":"Van Regenmortel","year":"2014","journal-title":"J Mol Recognit"},{"key":"10.1002\/jmr.2470-BIB0035|jmr2470-cit-0035","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1745-7580-6-S2-S1","article-title":"Computer aided selection of candidate vaccine antigens","volume":"6","author":"Flower","year":"2010","journal-title":"Immunome Res"},{"key":"10.1002\/jmr.2470-BIB0036|jmr2470-cit-0036","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2174\/156802612801319043","article-title":"A systems biology perspective on rational design of peptide vaccine against virus infections","volume":"12","author":"Chen","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"10.1002\/jmr.2470-BIB0037|jmr2470-cit-0037","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6807-7-64","article-title":"Antibody-protein interactions: benchmark datasets and prediction tools evaluation","volume":"7","author":"Ponomarenko","year":"2007","journal-title":"BMC Struct Biol"},{"key":"10.1002\/jmr.2470-BIB0038|jmr2470-cit-0038","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btu190","article-title":"Improving B-cell epitope prediction and its application to global antibody-antigen docking","author":"Krawczyk","year":"2014","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1002\/jmr.2470-BIB0039|jmr2470-cit-0039","doi-asserted-by":"crossref","first-page":"e11653","DOI":"10.1371\/journal.pone.0011653","article-title":"A comparative approach linking molecular dynamics of altered peptide ligands and MHC with in vivo immune responses","volume":"5","author":"Knapp","year":"2010","journal-title":"PLoS One"},{"key":"10.1002\/jmr.2470-BIB0040|jmr2470-cit-0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/157340910791760073","article-title":"Conformational flexibility in designing peptides for immunology: the molecular dynamics approach","volume":"6","author":"Stavrakoudis","year":"2010","journal-title":"Curr Comput Aided Drug Des"},{"key":"10.1002\/jmr.2470-BIB0041|jmr2470-cit-0041","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/omi.2007.0037","article-title":"Prediction of epitopes in hemagglutinin and neuraminidase proteins of influenza A virus H5N1 strain: a clue for diagnostic and vaccine development","volume":"12","author":"Somvanshi","year":"2008","journal-title":"OMICS"},{"key":"10.1002\/jmr.2470-BIB0042|jmr2470-cit-0042","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.1186430","article-title":"Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus","volume":"328","author":"Xu","year":"2010","journal-title":"Science"},{"issue":"12","key":"10.1002\/jmr.2470-BIB0043|jmr2470-cit-0043","doi-asserted-by":"crossref","first-page":"e15877","DOI":"10.1371\/journal.pone.0015877","article-title":"Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes","volume":"5","author":"J\u00f8rgensen","year":"2010","journal-title":"PLoS One"},{"key":"10.1002\/jmr.2470-BIB0044|jmr2470-cit-0044","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1699-0463.1994.tb04871.x","article-title":"Rules for peptide binding to MHC class II molecules","volume":"102","author":"Sinigaglia","year":"1994","journal-title":"APMIS"},{"key":"10.1002\/jmr.2470-BIB0045|jmr2470-cit-0045","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(93)90490-H","article-title":"The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2","volume":"75","author":"Madden","year":"1993","journal-title":"Cell"},{"key":"10.1002\/jmr.2470-BIB0046|jmr2470-cit-0046","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jmr.2470-BIB0047|jmr2470-cit-0047","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0161-5890(01)00069-4","article-title":"Presentation of antigens by MHC class II molecules: getting the most out of them","volume":"38","author":"Villadangos","year":"2001","journal-title":"Mol Immunol"},{"key":"10.1002\/jmr.2470-BIB0048|jmr2470-cit-0048","first-page":"365","article-title":"The structure and function of the hemagglutinin membrane glycoprotein of influenza virus","volume":"56","author":"Wiley","year":"1987","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"10.1002\/jmr.2470-BIB0049|jmr2470-cit-0049","doi-asserted-by":"crossref","first-page":"13522","DOI":"10.1073\/pnas.1014854108","article-title":"Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population","volume":"108","author":"Meroz","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jmr.2470-BIB0050|jmr2470-cit-0050","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.4049\/jimmunol.170.4.1917","article-title":"Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6","volume":"170","author":"M\u00e9nez","year":"2003","journal-title":"J Immunol"},{"key":"10.1002\/jmr.2470-BIB0051|jmr2470-cit-0051","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1084\/jem.175.6.1799","article-title":"Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif","volume":"175","author":"Kropshofer","year":"1992","journal-title":"J Exp Med"},{"key":"10.1002\/jmr.2470-BIB0052|jmr2470-cit-0052","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1074\/jbc.M112.431346","article-title":"Unique features of the antiparallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A\/p66\u03b1)","volume":"288","author":"Walavalkar","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1002\/jmr.2470-BIB0053|jmr2470-cit-0053","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and AutoDock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J Comput Aided Mol Des"},{"key":"10.1002\/jmr.2470-BIB0054|jmr2470-cit-0054","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bioinformatics\/btg371","article-title":"ClusPro: an automated docking and discrimination method for the prediction of protein complexes","volume":"20","author":"Comeau","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1002\/jmr.2470-BIB0055|jmr2470-cit-0055","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10822-007-9159-2","article-title":"An improved relaxed complex scheme for receptor flexibility in computer-aided drug design","volume":"22","author":"Amaro","year":"2008","journal-title":"J Comput Aided Mol Des"},{"key":"10.1002\/jmr.2470-BIB0056|jmr2470-cit-0056","doi-asserted-by":"crossref","DOI":"10.1142\/S0219720012410120","article-title":"Modeling of three dimensional structure of human alpha-fetoprotein complexed with diethylstilbestrol: docking and molecular dynamics simulation study","volume":"10","author":"Terentiev","year":"2012","journal-title":"J Bioinform Comput Biol"},{"key":"10.1002\/jmr.2470-BIB0057|jmr2470-cit-0057","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1021\/jm7012198","article-title":"Combining docking, molecular dynamics and the linear interaction energy method to predict binding modes and affinities for nonnucleoside inhibitors to HIV-1 reverse transcriptase","volume":"51","author":"Carlsson","year":"2008","journal-title":"J Med Chem"},{"key":"10.1002\/jmr.2470-BIB0058|jmr2470-cit-0058","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bbamem.2010.12.004","article-title":"Homology modeling of human CCR5 and analysis of its binding properties through molecular docking and molecular dynamics simulation","volume":"1808","author":"Shahlaei","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jmr.2470-BIB0059|jmr2470-cit-0059","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/prot.21698","article-title":"Implicit flexibility in protein docking: cross-docking and local refinement","volume":"69","author":"Kr\u00f3l","year":"2007","journal-title":"Proteins"},{"key":"10.1002\/jmr.2470-BIB0060|jmr2470-cit-0060","doi-asserted-by":"crossref","first-page":"154115","DOI":"10.1063\/1.4759036","article-title":"Fast convergence to equilibrium for long-chain polymer melts using a MD\/continuum hybrid method","volume":"137","author":"Senda","year":"2012","journal-title":"J Chem Phys"},{"key":"10.1002\/jmr.2470-BIB0061|jmr2470-cit-0061","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/prot.21308","article-title":"Convergence of molecular dynamics simulations of membrane proteins","volume":"67","author":"Grossfield","year":"2007","journal-title":"Proteins"},{"key":"10.1002\/jmr.2470-BIB0062|jmr2470-cit-0062","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/prot.10144","article-title":"Assessing equilibration and convergence in biomolecular simulations","volume":"48","author":"Smith","year":"2002","journal-title":"Proteins"},{"key":"10.1002\/jmr.2470-BIB0063|jmr2470-cit-0063","doi-asserted-by":"crossref","first-page":"24141","DOI":"10.1074\/jbc.M313210200","article-title":"De novo design of peptide immunogens that mimic the coiled coil region of human T-cell leukemia virus type-1 glycoprotein 21 transmembrane subunit for induction of native protein reactive neutralizing antibodies","volume":"279","author":"Sundaram","year":"2004","journal-title":"Biol Chem"},{"key":"10.1002\/jmr.2470-BIB0064|jmr2470-cit-0064","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1016\/S0021-9258(18)42700-7","article-title":"Design and immunological properties of topographic immunogenic determinants of a protein antigen (LDH-C4) as vaccines","volume":"267","author":"Kaumaya","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1002\/jmr.2470-BIB0065|jmr2470-cit-0065","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/S0264-410X(02)00148-2","article-title":"Effective synthetic peptide vaccine for foot-and-mouth disease in swine","volume":"20","author":"Wang","year":"2002","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0066|jmr2470-cit-0066","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.vaccine.2005.01.031","article-title":"An ingenious design for peptide vaccines","volume":"23","author":"Yano","year":"2005","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0067|jmr2470-cit-0067","first-page":"197","article-title":"GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines","volume":"54","author":"Helling","year":"1994","journal-title":"Cancer Res"},{"key":"10.1002\/jmr.2470-BIB0068|jmr2470-cit-0068","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0264-410X(03)00561-9","article-title":"RGD motif enhances immunogenicity and adjuvanicity of peptide antigens following intranasal immunization","volume":"22","author":"Yano","year":"2003","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0069|jmr2470-cit-0069","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/vim.2010.0137","article-title":"Estimation of seroprevalence of the pandemic H1N1 2009 influenza virus using a novel virus-free ELISA assay for the detection of specific antibodies","volume":"24","author":"Mavrouli","year":"2011","journal-title":"Viral Immunol"},{"key":"10.1002\/jmr.2470-BIB0070|jmr2470-cit-0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12026-013-8385-z","article-title":"Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts","volume":"56","author":"Loyola","year":"2013","journal-title":"Immunol Res"},{"key":"10.1002\/jmr.2470-BIB0071|jmr2470-cit-0071","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1128\/IAI.41.2.540-545.1983","article-title":"Hemagglutinin-specific antibody responses in immunoglobulin G, A, and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus","volume":"41","author":"Burlington","year":"1983","journal-title":"Infect Immun"},{"key":"10.1002\/jmr.2470-BIB0072|jmr2470-cit-0072","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0022-1759(90)90399-G","article-title":"A novel enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to HIV-1 envelope glycoproteins based on immobilization of viral glycoproteins in microtiter wells coated with concanavalin A","volume":"132","author":"Robinson","year":"1990","journal-title":"J Immunol Methods"},{"key":"10.1002\/jmr.2470-BIB0073|jmr2470-cit-0073","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1128\/CVI.00555-10","article-title":"Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza","volume":"18","author":"Chan","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1002\/jmr.2470-BIB0074|jmr2470-cit-0074","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/JCM.22.2.250-254.1985","article-title":"Simplified plaque reduction neutralization assay for dengue viruses by semimicromethods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralization","volume":"22","author":"Morens","year":"1985","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmr.2470-BIB0075|jmr2470-cit-0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1073\/pnas.82.1.178","article-title":"Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein","volume":"82","author":"Geysen","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1002\/jmr.2470-BIB0076|jmr2470-cit-0076","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1371\/journal.pbio.0030091","article-title":"The immune epitope database and analysis resource: from vision to blueprint","volume":"3","author":"Peters","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1002\/jmr.2470-BIB0077|jmr2470-cit-0077","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1128\/JVI.64.3.1283-1289.1990","article-title":"Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1","volume":"64","author":"Wiegers","year":"1990","journal-title":"J Virol"},{"key":"10.1002\/jmr.2470-BIB0078|jmr2470-cit-0078","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/bioinformatics\/btl012","article-title":"Discontinuous epitope prediction based on mimotope analysis","volume":"22","author":"Moreau","year":"2006","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1002\/jmr.2470-BIB0079|jmr2470-cit-0079","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.it.2003.10.006","article-title":"Towards in silico prediction of immunogenic epitopes","volume":"24","author":"Flower","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1002\/jmr.2470-BIB0080|jmr2470-cit-0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF03402006","article-title":"Methods for prediction of peptide binding to MHC molecules: a comparative study","volume":"8","author":"Yu","year":"2002","journal-title":"Mol Med"},{"issue":"1","key":"10.1002\/jmr.2470-BIB0081|jmr2470-cit-0081","doi-asserted-by":"crossref","first-page":"e8553","DOI":"10.1371\/journal.pone.0008553","article-title":"Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin","volume":"5","author":"Igarashi","year":"2010","journal-title":"PLoS One"},{"key":"10.1002\/jmr.2470-BIB0082|jmr2470-cit-0082","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.micinf.2010.01.001","article-title":"Research and development of universal influenza vaccines","volume":"12","author":"Du","year":"2010","journal-title":"Microbes Infect"},{"key":"10.1002\/jmr.2470-BIB0083|jmr2470-cit-0083","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1128\/IAI.66.2.786-793.1998","article-title":"Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB\/c mice","volume":"66","author":"Taborda","year":"1998","journal-title":"Infect Immun"},{"key":"10.1002\/jmr.2470-BIB0084|jmr2470-cit-0084","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/j.1460-2075.1988.tb02787.x","article-title":"A sequence pattern common to T cell epitopes","volume":"7","author":"Rothbard","year":"1988","journal-title":"EMBO J"},{"key":"10.1002\/jmr.2470-BIB0085|jmr2470-cit-0085","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.vaccine.2012.12.083","article-title":"A novel method for enhancement of peptide vaccination utilizing T-cell epitopes from conventional vaccines","volume":"31","author":"Yano","year":"2013","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0086|jmr2470-cit-0086","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bbapap.2010.04.004","article-title":"Biochemical and structural consequences of a glycine deletion in the alpha-8 helix of protoporphyrinogenoxidase","volume":"1804","author":"Dayan","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jmr.2470-BIB0087|jmr2470-cit-0087","doi-asserted-by":"crossref","first-page":"40163","DOI":"10.1074\/jbc.M111.283564","article-title":"Loss of T cell antigen recognition arising from changes in peptide and major histocompatibility complex protein flexibility: implications for vaccine design","volume":"86","author":"Insaidoo","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1002\/jmr.2470-BIB0088|jmr2470-cit-0088","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.4049\/jimmunol.0802228","article-title":"The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9","volume":"183","author":"James","year":"2009","journal-title":"J Immunol"},{"key":"10.1002\/jmr.2470-BIB0089|jmr2470-cit-0089","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbrc.2005.03.102","article-title":"Allele effects in MHC-peptide interactions: a theoretical analysis of HLA-DRbeta1*0101-HA and HLADRbeta1* 0401-HA complexes","volume":"330","author":"C\u00e1rdenas","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1002\/jmr.2470-BIB0090|jmr2470-cit-0090","doi-asserted-by":"crossref","first-page":"e2403","DOI":"10.1371\/journal.pone.0002403","article-title":"Model for the peptide-free conformation of class II MHC proteins","volume":"3","author":"Painter","year":"2008","journal-title":"PLoS One"},{"key":"10.1002\/jmr.2470-BIB0091|jmr2470-cit-0091","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.iy.02.040184.000435","article-title":"The antigenic structure of proteins: a reappraisal","volume":"2","author":"Benjamin","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jmr.2470-BIB0092|jmr2470-cit-0092","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1016\/j.vaccine.2010.05.012","article-title":"Identification and characterization of nematode specific protective epitopes of Brugia malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis","volume":"28","author":"Madhumathi","year":"2010","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0093|jmr2470-cit-0093","doi-asserted-by":"crossref","first-page":"26279","DOI":"10.1016\/S0021-9258(19)74312-9","article-title":"Antigenicity and immunogenicity of modified synthetic peptides containing D-amino acid residues","volume":"268","author":"Benkirane","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1002\/jmr.2470-BIB0094|jmr2470-cit-0094","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.diagmicrobio.2010.07.015","article-title":"Evaluation of synthetic peptides of WbSXP-1 for the diagnosis of human lymphatic filariasis","volume":"68","author":"Pandiaraja","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1002\/jmr.2470-BIB0095|jmr2470-cit-0095","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.23.021704.115658","article-title":"How TCRs bind MHCs, peptides, and coreceptors","volume":"24","author":"Rudolph","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jmr.2470-BIB0096|jmr2470-cit-0096","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.immunol.26.021607.090248","article-title":"Mechanism and regulation of class switch recombination","volume":"26","author":"Stavnezer","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jmr.2470-BIB0097|jmr2470-cit-0097","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jmr.2470-BIB0098|jmr2470-cit-0098","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1084\/jem.20020327","article-title":"Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation","volume":"196","author":"Lennon-Dum\u00e9nil","year":"2002","journal-title":"J Exp Med"},{"key":"10.1002\/jmr.2470-BIB0099|jmr2470-cit-0099","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1108003","article-title":"Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate","volume":"307","author":"Delamarre","year":"2005","journal-title":"Science"},{"key":"10.1002\/jmr.2470-BIB0100|jmr2470-cit-0100","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.2422757","article-title":"Mapping epitopes on a protein antigen by the proteolysis of antigen-antibody complexes","volume":"232","author":"Jemmerson","year":"1986","journal-title":"Science"},{"key":"10.1002\/jmr.2470-BIB0101|jmr2470-cit-0101","first-page":"37","volume-title":"Fundamental immunology","author":"Frazer","year":"1999"},{"key":"10.1002\/jmr.2470-BIB0102|jmr2470-cit-0102","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1128\/JVI.00273-13","article-title":"Identification of dominant antibody-dependent cell-mediated cytotoxicity epitopes on the hemagglutinin antigen of pandemic H1N1 influenza virus","volume":"87","author":"Srivastava","year":"2013","journal-title":"J Virol"},{"key":"10.1002\/jmr.2470-BIB0103|jmr2470-cit-0103","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/CVI.05518-11","article-title":"Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection","volume":"19","author":"Gordon","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1002\/jmr.2470-BIB0104|jmr2470-cit-0104","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2105-8-424","article-title":"Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction","volume":"8","author":"Larsen","year":"2007","journal-title":"BMC Bioinf"},{"key":"10.1002\/jmr.2470-BIB0105|jmr2470-cit-0105","doi-asserted-by":"crossref","first-page":"297505","DOI":"10.1155\/2010\/297505","article-title":"Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development","volume":"2010","author":"He","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1002\/jmr.2470-BIB0106|jmr2470-cit-0106","doi-asserted-by":"crossref","first-page":"W612","DOI":"10.1093\/nar\/gkp417","article-title":"SEPPA: a computational server for spatial epitope prediction of protein antigens","volume":"37","author":"Sun","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/jmr.2470-BIB0107|jmr2470-cit-0107","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1016\/j.vaccine.2011.02.019","article-title":"Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus","volume":"29","author":"Schanen","year":"2011","journal-title":"Vaccine"},{"key":"10.1002\/jmr.2470-BIB0108|jmr2470-cit-0108","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.4049\/jimmunol.160.7.3363","article-title":"Several common HLA-DR types share largely overlapping peptide binding repertoires","volume":"160","author":"Southwood","year":"1998","journal-title":"J Immunol"},{"key":"10.1002\/jmr.2470-BIB0109|jmr2470-cit-0109","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0814s24","article-title":"Using AutoDock for ligand-receptor docking","author":"Morris","year":"2008","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1002\/jmr.2470-BIB0110|jmr2470-cit-0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J Chem Theory Comput"},{"key":"10.1002\/jmr.2470-BIB0111|jmr2470-cit-0111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/104063871002200102","article-title":"Detection of anti-influenza A nucleoprotein antibodies in pigs using a commercial influenza epitope-blocking enzyme-linked immunosorbent assay developed for avian species","volume":"22","author":"Ciacci-Zanella","year":"2010","journal-title":"J Vet Diagn Invest"},{"key":"10.1002\/jmr.2470-BIB0112|jmr2470-cit-0112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0166-0934(98)00071-8","article-title":"Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro","volume":"74","author":"Rimmelzwaan","year":"1998","journal-title":"J Virol Methods"},{"key":"10.1002\/jmr.2470-BIB0113|jmr2470-cit-0113","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","article-title":"Prediction of residues in discontinuous B-cell epitopes using protein 3D structures","volume":"15","author":"Haste-Andersen","year":"2006","journal-title":"Protein Sci"}],"container-title":["Journal of Molecular Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmr.2470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jmr.2470\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T17:38:23Z","timestamp":1691516303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmr.2470"}},"subtitle":["Immunogenic Peptide against Pandemic Influenza AH1N1"],"short-title":[],"issued":{"date-parts":[[2015,3,18]]},"references-count":113,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1002\/jmr.2470","relation":{},"ISSN":["0952-3499"],"issn-type":[{"value":"0952-3499","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,18]]}}}