{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:05:22Z","timestamp":1760853922505,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Influenza virus has had a high rate of antigenic shift and drift that causes significant morbidity and mortality in humans and animals. The lack of excellent pharmacological treatment underlines the importance of the development of the novel antiviral drugs. We investigated the anti\u2010influenza A and B viruses of 2,4\u2010dichlorophenoxyacetic acid (2,4\u2010D), which is the synthetic analog to auxin and is used as a popular herbicide in the agricultural practices. 2,4\u2010D was evaluated using a cytopathic effect reduction method; assay results showed that 2,4\u2010D possessed strong anti\u2010influenza A and B viruses inhibiting the formation of a visible cytopathic effect. Influenza viral RNA expression was performed by quantitative real\u2010time polymerase chain reaction. 2,4\u2010D also inhibited virus replication in the early stage of influenza virus infection without direct interaction with virus particles. Additionally, 2,4\u2010D significantly inhibited various factors occur during influenza virus infection as the acidic vesicular formation and reactive oxygen species production. Moreover, 2,4\u2010D represented no cytotoxicity in normal kidney cell. Therefore, these findings provide an understanding of the mechanism and efficient use of 2,4\u2010D in pharmacological applications against influenza virus infection.<\/jats:p>","DOI":"10.1002\/jmr.2616","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T06:46:48Z","timestamp":1487918808000},"source":"Crossref","is-referenced-by-count":11,"title":["Inhibitory effect of 2,4\u2010dichlorophenoxyacetic acid on ROS, autophagy formation, and mRNA replication for influenza virus infection"],"prefix":"10.1002","volume":"30","author":[{"given":"Gansukh","family":"Enkhtaivan","sequence":"first","affiliation":[{"name":"Department of Bioresources and Food Science Konkuk University  Seoul 143\u2010701 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pandurangan","family":"Muthuraman","sequence":"additional","affiliation":[{"name":"Department of Bioresources and Food Science Konkuk University  Seoul 143\u2010701 South 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