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QDs contribute to the adverse effects of organisms probably because of the ability to induce oxidative stress via changing the activity of antioxidant enzyme, for example, superoxide dismutase (SOD). But the underlying molecular mechanisms still remain unclear. This study investigated the harmful effects of oxidative stress induced by mercaptopropionic acid capped CdTe QDs (MPA\u2010CdTe QDs) on the mouse primary nephrocytes as well as the structure and function of SOD molecule and explored the underlying molecular mechanism. After 24\u2010hour MPA\u2010CdTe QD exposure, the activation level of extracellular regulated protein kinase (ERK) signaling pathway and cysteinyl\u2010directed aspartate\u2010specific proteases (Caspases) significantly increased, which led to the increasing level of reactive oxygen species (ROS) and cell apoptosis; the group pretreated with ROS scavenger <jats:italic>N<\/jats:italic>\u2010acetyl\u2010L\u2010cysteine (NAC) significantly reduced the apoptotic cell percentage, indicating that ROS played a critical role in QD\u2010induced cytotoxicity. Further molecular experiments showed that the interacting processes between the MPA\u2010CdTe QDs and SOD were spontaneous which changed the conformation, secondary structure of SOD. The interaction significantly resulted in the tightening of polypeptide chains and the shrinkage of SOD, leading to the inhibition of molecular SOD activity. This study demonstrates the adverse effects of QDs, revealing their potential risk in biomedical applications.<\/jats:p>","DOI":"10.1002\/jmr.2783","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T07:03:19Z","timestamp":1556780599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conformational and functional effects of MPA\u2010CdTe quantum dots on SOD: Evaluating the mechanism of oxidative stress induced by quantum dots in the mouse nephrocytes"],"prefix":"10.1002","volume":"32","author":[{"given":"Minglu","family":"Hao","sequence":"first","affiliation":[{"name":"School of Environmental Science and Engineering, Shandong University, China\u2010America CRC for Environment and Health  Qingdao 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