{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:35:58Z","timestamp":1791999358573,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enteric protozoan parasite, <jats:italic>Entamoeba histolytica (Eh)<\/jats:italic>, is the causative agent of amoebic dysentery and liver abscess in humans. It infects around 50 million people worldwide, which is a third general cause of death from parasitic diseases after malaria and schistosomiasis. The other prevalent form of the disease is <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Visceral_leishmaniasis\">Visceral leishmaniasis<\/jats:ext-link> caused by <jats:italic>Leishmania donovani<\/jats:italic> which is a human blood parasite. On the other hand, the <jats:italic>Toxoplasma gondii<\/jats:italic> is an obligate intracellular protozoan parasite; it causes serious opportunistic infections in HIV\u2010positive persons. The biological processes in all living organisms are mostly mediated by the proteins, and recognizing new target proteins and finding their function in pathogenesis will help in choosing better diagnostic markers. In eukaryotes, Rab protein plays a major role in pathogenesis. Rabs represent the largest branch in the Ras superfamily of GTPases. Among them, the Rab5 is important in the endocytosis and thus involved in pathogenesis. In this paper, we discussed the physiochemical profiling, modelling, and docking of the Rab5 protein from pathogenic species that is <jats:italic>Entamoeba histolytica<\/jats:italic>, <jats:italic>Leishmania donovani<\/jats:italic>, and <jats:italic>Toxoplasma gondii<\/jats:italic>. The modeled structures from this study and the key residues identified would give a better understanding of the three\u2010dimensional structure and functional insights into these proteins and help in developing new drug targets.<\/jats:p>","DOI":"10.1002\/jmr.2808","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T06:10:10Z","timestamp":1566367810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A comparative <i>in silico<\/i> analysis of Rab5 proteins from pathogenic species to find its role in the pathogenesis"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-2051","authenticated-orcid":false,"given":"Vijay Kumar","family":"Srivastava","sequence":"first","affiliation":[{"name":"Amity Institute of Biotechnology Amity University Rajasthan  Kant Kalwar Jaipur 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