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In this study, a simple and sensitive fluorescent sensor for the determination of the cefixime and ctDNA was established based on the CdTe:Zn<jats:sup>2+<\/jats:sup> quantum dots (QDs). The fluorescence of CdTe:Zn<jats:sup>2+<\/jats:sup> QDs can be effectively quenched by cefixime in virtue of the surface binding of cefixime on CdTe:Zn<jats:sup>2+<\/jats:sup> QDs and the subsequent photoinduced electron transfer process from CdTe:Zn<jats:sup>2+<\/jats:sup> QDs to cefixime, in particular, the high sensitivity of QDs fluorescence emission to cefixime at the micromole per liter level, which render the cefixime\u2010CdTe:Zn<jats:sup>2+<\/jats:sup> QDs system into fluorescence \u201cOFF\u201d status, then turn on in the presence of ctDNA. Furthermore, the Fourier transform infrared (FTIR) spectra of characteristic bands of C\u2013N and N\u2013H groups of cefixime endow evidence for the interaction of cefixime with CdTe:Zn<jats:sup>2+<\/jats:sup> QDs. The relative electrochemical behavior of the affinity of CdTe:Zn<jats:sup>2+<\/jats:sup> QDs for cefixime and ctDNA reveals the potential molecular binding mechanism.<\/jats:p>","DOI":"10.1002\/jmr.2816","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T17:47:38Z","timestamp":1579196858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A sensitive fluorescent sensor based on the photoinduced electron transfer mechanism for cefixime and ctDNA"],"prefix":"10.1002","volume":"33","author":[{"given":"Cheng\u2010Zhang","family":"Yang","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering Hubei Normal University  Huangshi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key 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