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Designed DPA\u2010GQD respond to Hg<jats:sup>2+<\/jats:sup>, Cu<jats:sup>2+<\/jats:sup>, Au<jats:sup>2+<\/jats:sup>, Ag<jats:sup>+<\/jats:sup>, Co<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and Pb<jats:sup>2+<\/jats:sup> with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg<jats:sup>2+<\/jats:sup>, Cu<jats:sup>2+<\/jats:sup>, Au<jats:sup>2+<\/jats:sup>, Ag<jats:sup>+<\/jats:sup>, Co<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and Pb<jats:sup>2+<\/jats:sup>. In this work, a promising probe for ions monitoring was introduced. Moreover, DPA\u2010GQD probe has been tested in plasma samples. 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