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In this contribution, binding interactions of Qu and Qu\u2013metal complexes with calf thymus DNA (ctDNA) were investigated and compared systematically by using spectroscopic techniques and viscosity measurement. UV\u2010vis absorption spectra of ctDNA\u2013compound systems showed obvious hypochromic effect. Relative viscosity and melting temperature of ctDNA increased after the addition of Qu and Qu\u2013metal complexes, and the change tendency is Qu\u2013Cr(III)\u2009&gt;\u2009Qu\u2013Mn(II)\u2009&gt;\u2009Qu\u2013Zn(II)\u2009&gt;\u2009Qu\u2013Cu(II)\u2009&gt;\u2009Qu. Fluorescence competition experiments show that hydrogen bonds and van der Waals interaction play an important role in the intercalative binding of Qu and Qu\u2013metal complexes with ctDNA. Qu and Qu\u2013metal complexes could unwind the right\u2010handed B\u2010form helicity of ctDNA and further affect its base pair stacking. Space steric hindrance might be responsible for the differences in the intercalative binding between ctDNA and different Qu\u2013metal complexes. These results provide new information for the molecular understanding of binding interactions of Qu\u2013metal complexes with DNA and the strategy for research of structural influences.<\/jats:p>","DOI":"10.1002\/jmr.2933","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T14:35:48Z","timestamp":1629902148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison on binding interactions of quercetin and its metal complexes with calf thymus <scp>DNA<\/scp> by spectroscopic techniques and viscosity measurement"],"prefix":"10.1002","volume":"34","author":[{"given":"Huajian","family":"Luo","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials Nanning Normal University  Nanning 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