{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:53:42Z","timestamp":1768726422579,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, a new sandwich\u2010type biosensor was developed to specific recognition of prostate\u2010specific antigen (PSA) and early\u2010stage diagnosis of prostate cancer using encapsulation of biotinylated antibody (Ab1) of prostate\u2010specific antigen on <jats:italic>D<\/jats:italic>\u2010penicillamine decorated wrinkled silicate nanoparticles (WSN). For the first time, KCC\u20101\u2010NH\u2010DPA was synthesized and used to immobilization of biomacromolecules. So, fabricated immunosensor was performed by on sandwich\u2010type strategy. After fabrication of immunosensor, cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry techniques were used to electrochemical evaluation of immune\u2010platform for PSA detection. The proposed biocompatibility immune\u2010platform provided a novel interface toward sensitive bioanalysis of PSA biomarker in human plasma samples. Due to the use of gold nanoparticles functionalized Cysteamine (Cys A) in the structure of the secondary antibody (Ab2 [HRP\u2010Ab2]), the intensity of the electrochemical signal has increased, resulting in a more accurate detection of the target molecules. Under the right conditions, the engineering immunosensor provides good bioanalytical performance for determining the PSA biomarker in the linear range of 0.002 to 60\u2009\u03bcg\u2009L<jats:sup>\u22121<\/jats:sup> which low limit of quantification was 0.002\u2009\u03bcg\u2009L<jats:sup>\u22121<\/jats:sup>. As a result, it is suggested to use these immune\u2010devices in the clinical pre\u2010diagnosis of prostate cancer.<\/jats:p>","DOI":"10.1002\/jmr.2960","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T14:35:55Z","timestamp":1650033355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sensitive recognition of prostate\u2010specific antigen using biotinylated antibody encapsulated on <i>D<\/i>\u2010penicillamine decorated wrinkled silicate nanoparticles (<scp>WSN<\/scp>): An innovative sandwich\u2010type biosensor toward diagnosis of prostate cancer"],"prefix":"10.1002","volume":"35","author":[{"given":"Milad Baghal","family":"Behyar","sequence":"first","affiliation":[{"name":"Pharmaceutical Analysis Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Food and Drug Safety Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Farshchi","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Hasanzadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analysis Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.12.070"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.07.056"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.04.036"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.07.064"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tsf.2007.08.048"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.08.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2410"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2013.10.075"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.10.057"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2010.08.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.05.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA04388E"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA05655G"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201003451"},{"key":"e_1_2_8_17_1","unstructured":"PolshettiwarV 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