{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:04:27Z","timestamp":1787454267217,"version":"build-2736575974"},"reference-count":84,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this research, a series of <jats:italic>N<\/jats:italic>\u2010phenylsulfonamide derivatives (<jats:bold>1<\/jats:bold>\u2010<jats:bold>12<\/jats:bold>) were designed, synthesized, and investigated for their inhibitory potencies against carbonic anhydrase isoenzymes I, II, and IX (hCA I, hCA II, and hCA IX) and cholinesterases (ChE), namely, acetylcholinesterase and butyrylcholinesterase. These compounds, whose inhibition potentials were evaluated for the first time, were characterized by spectroscopic techniques (<jats:sup>1<\/jats:sup>H\u2010 and <jats:sup>13<\/jats:sup>C\u2010NMR and FT\u2010IR). CA isoenzyme inhibitors are significant therapeutic targets, especially owing to their preventive\/activation potential in the therapy processes of some diseases such as cancer, osteoporosis, and glaucoma. On the other hand, Cholinesterase inhibitors are valuable molecules with biological importance that can be employed in the therapy process of Alzheimer's patients. The results showed that the tested molecules had enzyme inhibition activities ranging from 9.7 to 93.7\u00a0nM against these five metabolic enzymes. Among the tested molecules, the methoxy and the hydroxyl group\u2010containing compounds <jats:bold>10<\/jats:bold>, <jats:bold>11<\/jats:bold>, and <jats:bold>12<\/jats:bold> exhibited more enzyme inhibition activities when compared to standard compounds acetazolamide, sulfapyridine, and sulfadiazine for CA isoenzymes and neostigmine for ChE, respectively. Of these three molecules, compound <jats:bold>12<\/jats:bold>, which had a hydroxyl group in the <jats:italic>para<\/jats:italic> position in the aromatic ring, was determined to be the most active molecule against all enzymes. In silico work, molecular docking has also shown similar results and is consistent with the experimental data in the study. As a result, we can say that some of the tested molecules might be used as promising inhibitor candidates for further studies on this topic.<\/jats:p>","DOI":"10.1002\/jmr.2982","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T08:00:36Z","timestamp":1658044836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biological activity and molecular docking studies of some <i>N<\/i>\u2010phenylsulfonamides against cholinesterases and carbonic anhydrase isoenzymes"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-5919","authenticated-orcid":false,"given":"Ey\u00fcp","family":"Ba\u015faran","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies, Vocational School of Technical Sciences Batman University  Batman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7419","authenticated-orcid":false,"given":"Re\u015fit","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Medical Laboratory Techniques Program, Vocational School of Health Services Batman University  Batman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-7511","authenticated-orcid":false,"given":"Murat","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pharmacy Faculty A\u011fr\u0131 Ibrahim \u00c7ecen University  A\u011fr\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-8400","authenticated-orcid":false,"given":"Tugba","family":"Taskin\u2010Tok","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Chemistry Gaziantep University  Gaziantep Turkey"},{"name":"Institute of Health Sciences, Department of Bioinformatics and Computational Biology Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"The neuropathological diagnosis of Alzheimer's disease","volume":"14","author":"De Ture MA","year":"2019","journal-title":"Mol Neurodegener"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771700100X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1543288"},{"key":"e_1_2_8_5_1","first-page":"153","article-title":"A population\u2010based study of Dementia in 85\u2010year\u2010olds","volume":"328","author":"Skoog I","year":"1993","journal-title":"J Med"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)01219-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06279-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2013.15.4\/hjahn"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.12.1879"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.09.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.05.006"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Culturally appropriate assessment of depression and anxiety in Older Torres Strait Islanders: limitations and recommendations","author":"Russell SG","year":"2021","journal-title":"Australas J Ageing"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.10.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.3.2001787"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2017.15.1.1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.035"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1198901"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103134"},{"key":"e_1_2_8_20_1","first-page":"42","article-title":"Dog strategies in the transition economies","volume":"54","author":"Davis KL","year":"1999","journal-title":"J Geriatr"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00613-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110817"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3350095"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)10025-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990224w"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131425"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2010.18.1.065"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.04.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.012"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1094470"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.617745"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01389"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.178.345"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990479"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar7000588"},{"key":"e_1_2_8_37_1","first-page":"419","article-title":"Carbonic anhydrase isoenzymes CA I and CA II in the human eye","volume":"27","author":"Wistrand PJ","year":"1986","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.9.2752"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.08.019"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.048"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.01.048"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22456"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012365424900"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.12.2.217"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.08.033"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7359-2_17"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4009357"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500863j"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141092"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-011-9917-5"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.07.056"},{"key":"e_1_2_8_52_1","first-page":"1209","article-title":"Synthesis of N\u2010aryl substituted p\u2010toluenesulphonamides via nickel catalyzed amidation reaction and their antibacterial, antifungal and antioxidant activities evaluation","volume":"31","author":"Izuchukwu UD","year":"2018","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2022.109263"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.4426"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.2004923"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6312"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT03897C"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c00415"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22607"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104279"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1198900"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120678"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.621122"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900292"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00261"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01305a039"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01498a056"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.09.020"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.04.014"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01215a001"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.191304603207"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01375a023"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00349a013"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.021"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.12.016"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA13674A"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95800-X"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22210"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.11.003"},{"key":"e_1_2_8_81_1","unstructured":"Accelrys Software Inc.Discovery Studio Modeling Environment Release 3.5 Accelrys Software Inc San Diego 2013."},{"key":"e_1_2_8_82_1","unstructured":"FrischMJ TrucksGW SchlegelHB et al.Gaussian 09 Revision E.01 Gaussian Inc. Wallingford CT.2009."},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"}],"container-title":["Journal of Molecular Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.2982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmr.2982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.2982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:02:47Z","timestamp":1692748967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmr.2982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":84,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/jmr.2982"],"URL":"https:\/\/doi.org\/10.1002\/jmr.2982","archive":["Portico"],"relation":{},"ISSN":["0952-3499","1099-1352"],"issn-type":[{"value":"0952-3499","type":"print"},{"value":"1099-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"2022-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2982"}}