{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:09:59Z","timestamp":1776082199246,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22164003"],"award-info":[{"award-number":["22164003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21865032"],"award-info":[{"award-number":["21865032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The overdose of acetaminophen (AP) can cause serious acute liver injury even the irreversible liver necrosis. The quantitative detection of AP is of great significance not only for clinical applications but also for the quantity control of its pharmaceutical formulations. In this paper, a sensitive molecularly imprinted voltammetric sensor towards AP was constructed based on synergistic enhancement of nitrogen\u2010vacancy graphitized carbon nitride (NV\u2010g\u2010C<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub>) and carboxylated MWCNTs loaded with silver nanoparticles (Ag\u2010MWCNTs). The powder X\u2010Ray diffraction spectrum, field emission scanning and transmission electron microscopes, cyclic voltammetry (CV), and electrochemical impedance spectrum were used to characterize the composites. The results show that NV\u2010g\u2010C<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub> and Ag\u2010MWCNTs closely embedded each other, forming loose porous hybrid structure by hydrogen bond. The prepared sensor molecular imprinting polymer (MIP)\/C<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub>\/Ag\u2010CNTs\/GCE shows a strong synergistic enhancement of electroanalytical response by CV and differential pulse voltammetry (DPV) tests when compared with NV\u2010g\u2010C<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub>\/GCE, Ag\u2010CNTs\/GCE, and MIP\/GCE. Through the optimization of the ratio of monomer and template, electropolymerization cycle, elution cycle, incubation time, and pH, linear ranges of 0.007\u20105 and 5\u2010100\u2009\u03bcM were found with the limit of detection of 2.33\u2009nM by DPV. Moreover, its selectivity towards AP was satisfied when compared with detection towards ascorbic acid, dopamine, and glucose. The recovery range of 96.3%\u2010100.5% was obtained in the spiked human serum and urine samples with the SD below 3.0%. In addition, the prepared sensor shows great detecting robustness with good anti\u2010interference, reproducibility, and stability.<\/jats:p>","DOI":"10.1002\/jmr.2992","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T05:38:57Z","timestamp":1662961137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecularly imprinted voltammetric sensor sensibilized by nitrogen\u2010vacancy graphitized carbon nitride and Ag\u2010MWCNTs towards the detection of acetaminophen"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-0253","authenticated-orcid":false,"given":"Shufang","family":"Ren","sequence":"first","affiliation":[{"name":"Key Laboratory of Evidence Science Techniques Research and Application of Gansu Province Gansu University of Political Science and Law  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shounian","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Northwest Normal University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Northwest Normal University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Evidence Science Techniques Research and Application of Gansu Province Gansu University of Political Science and Law  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.07.009"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105262"},{"key":"e_1_2_13_4_1","first-page":"60","article-title":"Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs","volume":"19","author":"Luki\u0107 V","year":"2021","journal-title":"Chemis"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1149\/1945-7111\/abbb0d"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.08.075"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.137825"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122309"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100543"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2022.120750"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1119\/1\/012014"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tsf.2020.137875"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5296582"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.04.146"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-017-2200-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.201300050"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.126993"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.111819"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-016-1926-0"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121845"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.02.066"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.08.085"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1149\/2162-8777\/abd149"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112994"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-021-05128-x"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134766"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2014.04.002"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00075"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.66.195415"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.06.036"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19057"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2020.118693"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.09.042"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.08.048"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2018.09.007"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.08.067"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903545"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.10.010"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2019.107393"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi10040234"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2020.114309"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.126998"},{"key":"e_1_2_13_43_1","volume-title":"Synthesis of Carbon Nanotubes\/Agnanoparticles by Chemistry Reductionmethod and Electrochemistry Catalyticmechenism Research in Oxygen Reduction","author":"Yan DS","year":"2008"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.02.097"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.02.029"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3866\/PKU.WHXB201905056"},{"key":"e_1_2_13_47_1","first-page":"860413","article-title":"Polypyrrole conducting electroactive polymers: synthesis and stability studies","volume":"3","author":"Ansari R","year":"2006","journal-title":"E\u2010J Chem"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120222"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.01.128"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/celc.201901592"}],"container-title":["Journal of Molecular Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.2992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmr.2992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.2992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:53:16Z","timestamp":1692683596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmr.2992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jmr.2992"],"URL":"https:\/\/doi.org\/10.1002\/jmr.2992","archive":["Portico"],"relation":{},"ISSN":["0952-3499","1099-1352"],"issn-type":[{"value":"0952-3499","type":"print"},{"value":"1099-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]},"assertion":[{"value":"2022-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2992"}}