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The network biology describes the interactions among genes\/proteins encoding molecular mechanisms of biological processes, development, and diseases. Besides, all the molecular networks, protein\u2010protein Interaction Networks have been significant in distinguishing the pathogenesis of diseases and thereby drug discovery. The present meta\u2010analysis prioritizes novel disease indications viz. rare and orphan diseases associated with target Glutamate Ionotropic Receptor NMDA Type Subunit 1, GRIN1 using text mining knowledge\u2010based tools. Furthermore, ZINC database was virtually screened, and binding conformation of selected compounds was performed and resulted in the identification of Narciclasine (ZINC04097652) and Alvespimycin (ZINC73138787) as potential inhibitors. 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