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Hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (<jats:italic>Juglans regia<\/jats:italic>) seed coat (E\u2010WSC) on some metabolic enzymes (glutathione reductase (GR), paraoxonase\u20101 (PON1), aldose reductase (AR), sorbitol dehydrogenase (SDH), acetylcholinesterase (AChE), glutathione S\u2010transferase (GST), and butyrylcholinesterase (BChE)) activity in the liver, kidney, and heart of rats with Triton WR\u20101339\u2010induced hyperlipidemia. Rats were divided into five groups: control group, HL\u2010Control group (Triton WR\u20101339 400\u2009mg\/kg, i.p administered group), E\u2010 WSC\u2009+\u2009150 (150\u2009mg\/kg,o.d given group), E\u2010 WSC\u2009+\u2009300 (E\u2010 WSC 300\u2009mg\/kg, o.d given group) and HL+ E\u2010WSC\u2009+\u2009300 (Group receiving E\u2010 WSC 300\u2009mg\/kg, o.d 30\u2009min prior to administration of Triton WR\u20101339 400\u2009mg\/kg, i.p). In HL\u2010Control, AR, SDH, and BChE enzyme activity was significantly increased in all tissues compared to the control, while the activity of other studied enzymes was significantly decreased. The effects of hyperlipidemia on balance were improved and alterations in the activity of the investigated metabolic enzymes were prevented by E\u2010WSC. As a result, promising natural compounds that can be used as adjuvant therapy in the treatment of cognitive disorders and hyperlipidemia may be found in E\u2010WSC powder.<\/jats:p>","DOI":"10.1002\/jmr.3004","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T11:31:55Z","timestamp":1671535915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Assessment of hypolipidemic and anti\u2010inflammatory properties of walnut (<i>Juglans regia<\/i>) seed coat extract and modulates some metabolic enzymes activity in triton <scp>WR\u20101339\u2010induced<\/scp> hyperlipidemia in rat kidney, liver, and heart"],"prefix":"10.1002","volume":"36","author":[{"given":"Esra","family":"Palab\u0131y\u0131k","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University  Erzurum 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