{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:35:48Z","timestamp":1790825748880,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetes mellitus is one of the most critical health problems affecting the quality of life of people worldwide, especially in developing countries. According to the World Health Organization reports, the number of patients with diabetes is approximately 420 million, and this number is estimated to be 642 million in 2040. There are 2 main types of diabetes: Type 1 (T1DM), where the body cannot produce enough insulin, and Type 2 (T2DM), where the body cannot use insulin properly. Patients with T1DM are treated with insulin injections while oral glucose\u2010lowering drugs are used for patients with T2DM. Oral antihyperglycemic drugs used in the treatment of type 2 diabetes mellitus have different mechanisms. Among these, \u03b1\u2010Glucosidase and \u03b1\u2010amylase inhibitors are one of the most important inhibitors. The antidiabetic effect of the chalcones, which show rich activity, draws attention. This research aims to synthesize chalcone derivatives that could show potential antidiabetic activity. In this study, the inhibitory activity of the chalcone compounds (\n                    <jats:bold>4a<\/jats:bold>\n                    \u2010\n                    <jats:bold>4g, 5a\u20105g<\/jats:bold>\n                    ) was tested against \u03b1\u2010glucosidase and \u03b1\u2010amylase enzymes. Besides, molecular modeling was utilized to predict potential interactions of the synthesized compounds that exhibit inhibitory effects. In both in vitro and in silico studies, the analyses revealed that compound\n                    <jats:bold>5e<\/jats:bold>\n                    exhibits strong inhibitory effects against \u03b1\u2010glucosidase enzymes (Binding energy: \u22127.75\u2009kcal\/mol, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 28.88\u2009\u03bcM). Additionally, compound\n                    <jats:bold>4f<\/jats:bold>\n                    demonstrates encouraging inhibitory effects against \u03b1\u2010Amylase (Binding energy: \u221211.08\u2009kcal\/mol, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 46. 21\u2009\u03bcM).\n                  <\/jats:p>","DOI":"10.1002\/jmr.3061","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:24:23Z","timestamp":1695011063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of \u03b1\u2010glucosidase and \u03b1\u2010amylase inhibitory effects of phenoxy chalcones and molecular modeling studies"],"prefix":"10.1002","volume":"36","author":[{"given":"Bedriye Seda","family":"Kur\u015fun\u2010Aktar","sequence":"first","affiliation":[{"name":"Department of Hair Care and Beauty Services, Ye\u015filyurt Vocational School Malatya Turgut \u00d6zal University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevki","family":"Adem","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Tatar\u2010Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyad Ad\u0131l Hameed","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine El\u00e7in","family":"Oru\u00e7\u2010Emre","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Diabetes. retrieved Nov. 3 2021 fromhttps:\/\/www.who.int\/healthtopics\/diabetes"},{"key":"e_1_2_9_3_1","unstructured":"International Diabetes Federation.Diabetes now affects one in 10 adults worldwide. retrieved Nov. 8 2021 fromhttps:\/\/www.idf.org\/news\/240:diabetes-now-affects-one-in-10-adults-worldwide.html"},{"key":"e_1_2_9_4_1","unstructured":"https:\/\/www.tuseb.gov.tr\/tuhke\/uploads\/genel\/files\/dunya_diyabet_gunu_2021_son.pdf"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"1","article-title":"Potent \u03b1\u2010amylase inhibitory activity of Indian ayurvedic medicinal plants","volume":"11","author":"Zinjarde SS","year":"2011","journal-title":"BMC Complement Altern Med"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283650"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104489"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"482","article-title":"Synthesis and biological evaluation of novel chalcones bearing morpholine moiety as antiproliferative agents","volume":"42","author":"Aktar BSK","year":"2018","journal-title":"Turk J Chem"},{"key":"e_1_2_9_9_1","first-page":"991","article-title":"Condensation of nicotinaldehydes with phenylethanones: a convenient synthesis and biological activities of chalcones","volume":"59","author":"Ramya S","year":"2020","journal-title":"Indian J Chem"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.02.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA46492J"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.10.028"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112416"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.3020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.08.014"},{"key":"e_1_2_9_17_1","unstructured":"Antiproliferative activities of chalcone derivatives substituted with morpholine. National patent. Patent class: C07D 295\/04 Patent number: TR 2011 05601 B Registration date: 21.10.2013."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133994"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1549"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00585"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.32571\/ijct.1003871"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.03.002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.10.003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004586"},{"key":"e_1_2_9_26_1","volume-title":"Discovery Studio Modeling Environment, Release 2020","author":"Dassault Syst\u00e8mes BIOVIA","year":"2020"}],"container-title":["Journal of Molecular Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.3061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:44:37Z","timestamp":1696520677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmr.3061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jmr.3061"],"URL":"https:\/\/doi.org\/10.1002\/jmr.3061","archive":["Portico"],"relation":{},"ISSN":["0952-3499","1099-1352"],"issn-type":[{"value":"0952-3499","type":"print"},{"value":"1099-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]},"assertion":[{"value":"2023-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3061"}}