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Metabolomics research has been shown to be linked to pathophysiologic pathways in liver illnesses. The aim of this study was to investigate the serum metabolic profile of patients with chronic hepatitis C (CHC) infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Nuclear magnetic resonance (NMR) was used to evaluate the sera of 83 patients with CHC virus and 52 healthy control volunteers (NMR). Then, multivariate statistical analysis was used to find distinguishing metabolites between the two groups. Sixteen out of 40 metabolites including include 3\u2010HB, betaine, carnitine, creatinine, fucose, glutamine, glycerol, isopropanol, lysine, mannose, methanol, methionine, ornithine, proline, serine, and valine\u2014were shown to be significantly different between the CHC and normal control (NC) groups (variable importance in projection &gt;1 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). All the metabolic perturbations in this disease are associated with pathways of Glycine, serine, and threonine metabolism, glycerolipid metabolism, arginine and proline metabolism, aminoacyl\u2010tRNA biosynthesis, cysteine and methionine metabolism, alanine, aspartate, and glutamate metabolism. Multivariate statistical analysis constructed using these expressed metabolites showed CHC patients can be discriminated from NCs with high sensitivity (90%) and specificity (99%). The metabolomics approach may expand the diagnostic armamentarium for patients with CHC while contributing to a comprehensive understanding of disease mechanisms.<\/jats:p>","DOI":"10.1002\/jmr.3066","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T10:58:56Z","timestamp":1698922736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The metabolic fingerprint of chronic hepatitis C progression: Metabolome shifts and cutting\u2010edge diagnostic options"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8253-5169","authenticated-orcid":false,"given":"Amar","family":"Deep","sequence":"first","affiliation":[{"name":"Department of Medical Gastroenterology KGMU  Lucknow India"},{"name":"Experimental and Public Health Laboratory, Department of Zoology Lucknow University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchit","family":"Swaroop","sequence":"additional","affiliation":[{"name":"Experimental and Public Health Laboratory, Department of Zoology Lucknow University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-4994","authenticated-orcid":false,"given":"Durgesh","family":"Dubey","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-0281","authenticated-orcid":false,"given":"Atul","family":"Rawat","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Verma","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-8696","authenticated-orcid":false,"given":"Bikash","family":"Baisya","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Parihar","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology SGPGIMS  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-1388","authenticated-orcid":false,"given":"Sumit","family":"Rungta","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology KGMU  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i17.2436"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2019.08.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360704"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/429490"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i48.6455"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01825.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01927.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280632"},{"key":"e_1_2_10_13_1","first-page":"17","volume-title":"Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: a Perspective on Long\u2010Term Outcome. 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