{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:21:26Z","timestamp":1772266886042,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Molecular Recognition"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>G\u2010quadruplexes play a pivotal role in regulating various cellular processes, including gene expression and replication, making them essential structures in understanding, and manipulating cellular functions. The development of G\u2010quadruplex ligands holds significant promise in therapeutic and research applications, offering targeted tools to modulate G\u2010quadruplex structures and potentially influence critical biological pathways. An exciting frontier in G\u2010quadruplex research lies in the exploration of anionic ligands, and their profound impact on stabilizing and modulating G\u2010quadruplex DNA. In this study, the interaction of two anionic phthalocyanine compounds (Zinc (II) phthalocyanine 3,4\u2032,4\u2033,4\u2034\u2010tetrasulfonic acid, tetrasodium salt, <jats:bold>ZnAPC<\/jats:bold>; cobalt (II) phthalocyanine 3,4\u2032,4\u2033,4\u2034\u2010tetrasulfonic acid, tetrasodium salt, <jats:bold>CoAPC<\/jats:bold>) and three separate G\u2010quadruplex\u2010forming DNA sequences was investigated. Interactions were carried out by DNA polymerase stop studies along with spectroscopic studies. According to the results of experimental data, it was determined that <jats:bold>ZnAPC<\/jats:bold> actively interacts with the G\u2010quadruplex DNA structures. On the other hand, it was thought that the interaction with <jats:bold>CoAPC<\/jats:bold> was less and even occurred in simple electrostatic interactions. K<jats:sub>D<\/jats:sub> constants and B<jats:sub>max<\/jats:sub> constants for the interaction with <jats:bold>ZnAPC<\/jats:bold> were calculated. The K<jats:sub>D<\/jats:sub> constants for <jats:bold>ZnAPC<\/jats:bold> were found to be (1.16\u2009\u00b1\u20090.07)\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>, (9.75\u2009\u00b1\u2009.24)\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup> and (1.00\u2009\u00b1\u20090.36)\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup> M for AS1411, Vegf, and Tel21, respectively. Accordingly, it was concluded that <jats:bold>ZnAPC<\/jats:bold> interacts with G\u2010quadruplex DNA ligands effectively.<\/jats:p>","DOI":"10.1002\/jmr.3082","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T02:15:55Z","timestamp":1710296155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insights into the G\u2010quadruplex DNA interaction landscape: Comparative analysis of anionic Zn(II) and Co(II) phthalocyanine\u2010tetrasulfonate complexes"],"prefix":"10.1002","volume":"37","author":[{"given":"Efkan","family":"Ba\u011fda","sequence":"first","affiliation":[{"name":"Molecular Biology and Genetics, Faculty of Science Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00519"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-023-02233-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2023.103552"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad764"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c05220"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176318"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.05.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.200110"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080769"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc00956c"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04771-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules170910586"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120271"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz589"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201900692"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2008.06.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300566"},{"key":"e_1_2_8_19_1","volume":"37","author":"\u015eahin G, Ba\u011fda E, G\u00f6ktu\u011f Temiz \u00d6","journal-title":"J Mol\u00a0Recognit"}],"container-title":["Journal of Molecular Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmr.3082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T07:12:16Z","timestamp":1712733136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmr.3082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jmr.3082"],"URL":"https:\/\/doi.org\/10.1002\/jmr.3082","archive":["Portico"],"relation":{},"ISSN":["0952-3499","1099-1352"],"issn-type":[{"value":"0952-3499","type":"print"},{"value":"1099-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,12]]},"assertion":[{"value":"2024-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3082"}}