{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:06:04Z","timestamp":1760976364662},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,11,20]],"date-time":"2001-11-20T00:00:00Z","timestamp":1006214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to assess the effects of afterload reduction in asymptomatic patients with severe aortic regurgitation (AR) and maintained LV function by cine\u2010MRI. We studied 13 patients at baseline and after 0.2 mg\/kg Hydralazine (I.V.). Patients were stratified according to the volumetric LV response to acute afterload reduction: Group I comprised patients with improved LV response; Group II comprised patients with unchanged or deteriorated LV response. Baseline LV function and severity of AR were not significantly different between groups. However, regurgitant fraction decreased (50 \u00b1 12 vs. 36 \u00b1 9%; <jats:italic>P<\/jats:italic> &lt; 0.03) and cardiac output increased (4.9 \u00b1 1.4 vs. 7.1 \u00b1 1.6l\/minute; <jats:italic>P<\/jats:italic> &lt; 0,001) in Group I and remained unchanged in Group II (54 \u00b1 10 vs. 55 \u00b1 10%, <jats:italic>P<\/jats:italic> = n.s. and 5.5 \u00b1 1.4 vs. 6.6 \u00b1 0.9l\/minute; <jats:italic>P<\/jats:italic> = n.s.) during maximal vasodilation. Beat\u2010to\u2010beat analysis revealed a decrease of left ventricular endsystolic volume index in group I (48 \u00b1 13 vs. 37 \u00b1 9 ml\/beat; <jats:italic>P<\/jats:italic> &lt; 0.05) and no change in group II (61 \u00b1 20 vs. 62 \u00b1 20 ml\/beat; <jats:italic>P<\/jats:italic> = n.s.). In the natural history of chronic AR, the absence of improved LV performance during acute vasodilation using beat\u2010to\u2010beat analysis by MRI may identify patients with more advanced cardiac adaptation to chronic volume overload. J. Magn. Reson. Imaging 2001;14:693\u2013697. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmri.10015","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:20:51Z","timestamp":1030292451000},"page":"693-697","source":"Crossref","is-referenced-by-count":4,"title":["Afterload reduction in severe aortic regurgitation"],"prefix":"10.1002","volume":"14","author":[{"given":"Udo","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stefenelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Klaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Globits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90115-0"},{"key":"e_1_2_5_3_2","first-page":"64","article-title":"Adaptations of the left ventricle to chronic volume overload","volume":"35","author":"Ross J","year":"1974","journal-title":"Circ Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.28.1.49"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1702"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.1.31"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00180-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90868-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/archinte.1990.00390160035008","article-title":"Beneficial long\u2010term effects of Hydralazine in aortic regurgitation","volume":"150","author":"Dumesnil JG","year":"1990","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(76)80003-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.46.433"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91065-P"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90252-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80049-2"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409153311101"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060052"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.6.525"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90560-N"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.5.879"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.2.263"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90203-X"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.3.355"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90660-N"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.10015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.10015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:56:31Z","timestamp":1696881391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.10015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,20]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/jmri.10015"],"URL":"https:\/\/doi.org\/10.1002\/jmri.10015","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,20]]}}}