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The task design was as follows: two minutes normal breathing (rest) followed by two minutes HV, giving a basic four\u2010minute block that was repeated three times for a total scan time of 12 minutes for one run. Each subject performed the run both for SE\u2010EPI and GE\u2010EPI. Statistical analysis was performed to detect the area with significant cerebrovascular reactivity. The percentage signal change was also obtained for each cerebral region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both GE\u2010EPI and SE\u2010EPI showed globally significant signal decreases in the cerebral cortex. In GE\u2010EPI, the frontal cortex showed a larger signal decrease than the other gray matter tissues (<jats:italic>P<\/jats:italic> &lt; 0.05). In SE\u2010EPI, the differences among gray matter tissues except for the hippocampal formation were not significant. The hippocampal formation showed the largest signal change (<jats:italic>P<\/jats:italic> &lt; 0.05) in SE\u2010EPI, but no significant signal change was observed in GE\u2010EPI due to the presence of susceptibility artifacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>HV using SE\u2010EPI at 3\u2010T provides robust and reproducible signal decreases and may make the evaluation of the vascular reactivity in hippocampal formation feasible. J. Magn. Reson. Imaging 2002;15:23\u201330. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10028","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:33:59Z","timestamp":1030293239000},"page":"23-30","source":"Crossref","is-referenced-by-count":21,"title":["Regional differences of fMR signal changes induced by hyperventilation: Comparison between SE\u2010EPI and GE\u2010EPI at 3\u2010T"],"prefix":"10.1002","volume":"15","author":[{"given":"Shinji","family":"Naganawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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