{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:39:52Z","timestamp":1791506392575,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,28]],"date-time":"2002-02-28T00:00:00Z","timestamp":1014854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate uterine changes on MRI before and after GnRH analog (GnRHa) treatment in diffuse adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010one patients with MRI features suggestive of diffuse adenomyosis received GnRHa for 6 months. Diffuse adenomyosis was sub\u2010classified as: <jats:italic>symmetric<\/jats:italic> (symmetric\/ entire widening of the junctional zone [JZ]) and <jats:italic>asymmetric<\/jats:italic> (asymmetric\/ partial widening of JZ). Pre\u2010 and post\u2010high signal intensity (SI) foci and JZ width, and post\u2010demarcated change (interface of adenomyosis with the myometrium became more discrete with a concomitant decrease in JZ width) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before therapy, 15 of 18 <jats:italic>asymmetric<\/jats:italic> contained high SI foci compared to none of <jats:italic>symmetric.<\/jats:italic> After therapy, JZ width decreased (<jats:italic>P<\/jats:italic> &lt; 0.0001). Eight <jats:italic>asymmetric<\/jats:italic> and none of <jats:italic>symmetric<\/jats:italic> showed demarcated change with resolved high SI foci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest the use of GnRHa is associated with a decrease of JZ width in adenomyosis. <jats:italic>Asymmetric<\/jats:italic> adenomyosis with high SI foci appears to be the most sensitive to hormonal therapy. J. Magn. Reson. Imaging 2002;15:285\u2013290. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10060","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:10:52Z","timestamp":1030317052000},"page":"285-290","source":"Crossref","is-referenced-by-count":59,"title":["MR imaging of diffuse adenomyosis changes after GnRH analog therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Izumi","family":"Imaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ascher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuro","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199312000-00004"},{"key":"e_1_2_6_3_2","first-page":"538","article-title":"Treatment of adenomyosis with long\u2010term GnRH analogues: a case report","volume":"78","author":"Grow DR","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55704-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55703-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55702-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00193-U"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.2.3562836"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.2.2704819"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.3.8115630"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.1.8633139"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.2.2109336"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90092-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.5.1217"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199601000-00026"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.159.1.3952297"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.2.1707545"},{"key":"e_1_2_6_18_2","first-page":"837","volume-title":"Danforth\u2018s obstetrics and gynecology","author":"Braly PS","year":"1999"},{"key":"e_1_2_6_19_2","first-page":"1392","volume-title":"Ackerman\u2018s surgical pathology","author":"Rosai J","year":"1996"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.2.9456960"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.10060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.10060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:26:28Z","timestamp":1696926388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.10060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,28]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1002\/jmri.10060"],"URL":"https:\/\/doi.org\/10.1002\/jmri.10060","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,28]]}}}