{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:29:23Z","timestamp":1761154163651},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,3,27]],"date-time":"2002-03-27T00:00:00Z","timestamp":1017187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the feasibility of blood pool contrast\u2010enhanced magnetic resonance angiography (MRA) to visualize the arterial and venous vessel tree and to detect deep venous thrombosis (DVT) of the lower extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Nine consecutive patients with pulmonary embolism (mean age = 46 \u00b1 9) were randomized to various doses of NC100150 (between 0.75 and 6 mg of Fe\/kg of body weight). A T1\u2010weighted (T1W) 3D gradient recalled echo (GRE) sequence (TE = 2.0 msec, TR = 5.0 msec) was used. Two observers blinded to the dose of contrast agent assessed image quality, contrast attenuation, and appearance of thrombi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Qualitative assessment of overall MRA image quality and semiquantitative vessel scoring revealed good to excellent delineation of venous and arterial vessel segments independent of the dose of NC100150. However, quantitative region of interest analysis revealed a significantly higher signal\u2010to\u2010noise ratio (SNR) in the high\u2010dose group than in the mid\u2010 and low\u2010dose groups of NC100150 (<jats:italic>P<\/jats:italic> &lt; 0.01). Between dose groups, the SNR was independent of vessel type (artery or vein) and vessel segment localization (proximal or distal). All seven venous thrombi (mean length = 7.2 \u00b1 0.95cm) were characterized by a very low signal intensity (SI), which was only 16.6 \u00b1 7% of the SI in adjacent venous segments (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010quality MR angiograms of the lower extremities can be obtained using low concentrations of NC100150 in combination with a strong T1W 3D GRE sequence. The obvious delineation of venous thrombi suggests that this technique may be potentially used as a noninvasive \u201cone\u2010stop shopping\u201d tool in the evaluation of thromboembolic disease. J. Magn. Reson. Imaging 2002;15:429\u2013437. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10082","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:16:32Z","timestamp":1030317392000},"page":"429-437","source":"Crossref","is-referenced-by-count":20,"title":["MRA of the lower extremities in patients with pulmonary embolism using a blood pool contrast agent: Initial 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