{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:46:56Z","timestamp":1762998416122},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T00:00:00Z","timestamp":1061164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the dependence of occipital gray and white matter <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> on the Carr\u2010Purcell\u2010Meiboom\u2010Gill (CPMG) refocusing interval, thereby testing the basis of a novel functional magnetic resonance imaging (fMRI) method for blood volume quantification, and addressing recent questions surrounding <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> contrast in the occipital lobe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A CPMG sequence with 1 \u00d7 1 \u00d7 5 mm<jats:sup>3<\/jats:sup> resolution was used to quantify <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> in a single axial slice at the midlevel of the occipital lobe in 23 healthy adult volunteers. Refocusing intervals of 8, 11, and 22 msec were compared. A Bayesian classifier was used to classify a 1 \u00d7 1 \u00d7 1 mm<jats:sup>3<\/jats:sup> <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted three\u2010dimensional data set into gray matter, white matter, and cerebrospinal fluid, with an average 95% a posteriori probability used as the threshold for inclusion into a tissue\u2010specific region of interest (ROI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The usual <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> contrast between the gray and white matter (i.e., <jats:italic>T<\/jats:italic><jats:sub>2<jats:italic>GM<\/jats:italic><\/jats:sub> &gt; <jats:italic>T<\/jats:italic><jats:sub>2<jats:italic>WM<\/jats:italic><\/jats:sub>) was observed, with a highly significant effect of tissue type on the estimated <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22125<\/jats:sup>). The observed <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> gradually decreased with increasing refocusing interval, for a decrease of 3.3 \u00b1 1.5 msec in gray matter and 3.0 \u00b1 1.5 msec in white matter between the 8 and 22 msec refocusing interval acquisitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The observed <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> shortening is consistent with the effect of the dramatic decrease in <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of partly deoxygenated blood on this range of refocusing rates. J. Magn. Reson. Imaging 2003;18:302\u2013309. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10360","type":"journal-article","created":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T13:46:19Z","timestamp":1061559979000},"page":"302-309","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative <i>T<\/i><sub>2<\/sub> in the occipital lobe: The role of the CPMG refocusing rate"],"prefix":"10.1002","volume":"18","author":[{"given":"Bojana","family":"Stefanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Sled","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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