{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:58:13Z","timestamp":1775325493232,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:00:00Z","timestamp":1063929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the diagnostic performance of functional magnetic resonance cholangiography (fMRC) for the evaluation of anatomic and functional biliary disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>At 1.5 T, 39 MR examinations with conventional MRC and mangafodipir trisodium\u2010enhanced fMRC were retrospectively reviewed by three observers who recorded anatomic (duct dilation, stricture, filling defects) and functional (cholecystitis, obstruction) abnormalities in three modes: MRC alone, fMRC alone, and MRC and fMRC images together (combined\u2010MRC). Performance was determined by comparing findings with each mode to findings of invasive cholangiography (IC) and surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 75 biliary segments (correlated with IC), the sensitivity\/specificity for diagnosing dilation (<jats:italic>N<\/jats:italic> = 41) with MRC was 95%\/97%; with fMRC, 90%\/100%; with combined\u2010MRC, 100%\/97%. For stricture (<jats:italic>N<\/jats:italic> = 7), the sensitivity\/specificity of MRC was 86%\/98%; of fMRC, 43%\/100%; of combined\u2010MRC, 86%\/100%. For filling defects (<jats:italic>N<\/jats:italic> = 9), the sensitivity\/specificity of MRC was 91%\/98%; of fMRC, 82%\/100%; of combined\u2010MRC, 91%\/100%. For diagnosing obstruction (<jats:italic>N<\/jats:italic> = 9), the sensitivity\/specificity of MRC, fMRC, and combined\u2010MRC were 89%\/100%, 100%\/100%, and 100%\/100%, respectively. For surgically proven cholecystitis (<jats:italic>N<\/jats:italic> = 13), positive predictive values for diagnosing acute\/chronic cholecystitis for MRC were 33%\/40%; for fMRC, 100%\/50%; for combined\u2010MRC, 100%\/50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although single\u2010shot fast spin echo (SSFSE)\u2010MRC is valuable, the addition of fMRC increased diagnostic performance for functional biliary disorders. J. Magn. Reson. Imaging 2003;18:449\u2013460. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10369","type":"journal-article","created":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T10:38:07Z","timestamp":1064227087000},"page":"449-460","source":"Crossref","is-referenced-by-count":63,"title":["Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast\u2010enhanced magnetic resonance cholangiography"],"prefix":"10.1002","volume":"18","author":[{"given":"Laura M.","family":"Fayad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George 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