{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:22:54Z","timestamp":1790151774735,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T00:00:00Z","timestamp":1074643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the diffusion of vertebral body marrow with quantitative MR diffusion imaging and to examine whether differences exist between subjects with postmenopausal osteoporosis and premenopausal control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 44 consecutive women (mean age, 70 years) with documented bone mineral density (BMD) measured by dual energy x\u2010ray absorptiometry (T\u2010score) and 20 normal subjects (mean age, 28 years) were examined with echo\u2010planar diffusion imaging at 1.5 T using b values of 0, 20, 40, 60, 80, 100, 200, 300, 400, and 500 seconds\/mm<jats:sup>2<\/jats:sup>. Extravascular diffusion (D) and apparent diffusion coefficient (ADC) were calculated and results from both groups compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both D and ADC values tended to decrease with decreasing BMD. Mean D values were significantly lower in postmenopausal women with reduced BMD (0.42 \u00b1 0.12 \u00d7 10<jats:sup>\u20133<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/second) than normal premenopausal women (0.50 \u00b1 0.09 \u00d7 10<jats:sup>\u20133<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/second). Mean ADC values were significantly lower both in subjects with reduced BMD (0.41 \u00b1 0.10 \u00d7 10<jats:sup>\u20133<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/second) and normal BMD (0.43 \u00b1 0.08 \u00d7 10<jats:sup>\u20133<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/second) compared to normal controls (0.49 \u00b1 0.07 \u00d7 10<jats:sup>\u20133<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/second).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Accumulation of fatty bone marrow associated with osteoporosis is reflected by a decrease in D and ADC. Diffusion imaging may prove useful in the study of osteoporosis. J. Magn. Reson. Imaging 2004;19:222\u2013228. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.10453","type":"journal-article","created":{"date-parts":[[2004,1,22]],"date-time":"2004-01-22T10:01:37Z","timestamp":1074765697000},"page":"222-228","source":"Crossref","is-referenced-by-count":102,"title":["Bone marrow diffusion in osteoporosis: Evaluation with quantitative MR diffusion imaging"],"prefix":"10.1002","volume":"19","author":[{"given":"David K. W.","family":"Yeung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Y.S.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith M.C.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08827-X"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111096"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623782"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.3.8058958"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.206.2.9457185"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.2.9807585"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.75.891.750207"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2253011707"},{"key":"e_1_2_5_11_2","first-page":"1620","article-title":"Potential value of vertebral proton MR spectroscopy in determining bone weakness","volume":"22","author":"Schellinger D","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1695690"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.3.1740731"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080704"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080706"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)00096-L"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.3.r99fe17617"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1177"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2001.042002123.x"},{"key":"e_1_2_5_22_2","first-page":"165","article-title":"Characterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging","volume":"23","author":"Zhou XJ","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200010)13:6<321::AID-NBM651>3.0.CO;2-P"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.207.2.9577479"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700940205"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.215.3.r00jn42910"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1105"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.10453","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.10453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T02:25:02Z","timestamp":1697163902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.10453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,21]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1002\/jmri.10453"],"URL":"https:\/\/doi.org\/10.1002\/jmri.10453","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,21]]}}}