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Due to concerns that the altered contrast characteristics of FSE may interfere with the visualization of multiple sclerosis (MS) lesions, the sensitivity of T2\u2010weighted FSE sequences was compared to comparably weighted CSE sequences in the imaging of the brain in 100 patients with clinically suspected MS. The proton\u2010density FSE sequence revealed more MS lesions than its CSE counterpart, while the T2\u2010weighted CSE sequences were found to be more sensitive than the T2\u2010weighted FSE sequence. Contrast\u2010to\u2010noise ratios and signal\u2010to\u2010noise ratios compared favorably between sequences. Overall, there was little difference in the specificity between FSE and CSE in the diagnosis of MS. The higher sensitivity and the reduction in time attainable through the use of FSE warrants its replacement of CSE when imaging the brain in patients with clinically suspected MS. J. Magn. Reson. 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