{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:43:06Z","timestamp":1787740986524,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":4887,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The magnetization transfer contrast (MTC) technique was used in low\u2010field\u2010strength (0.1 T) magnetic resonance (MR) imaging of 28 patients with intracranial tumors. MTC images were generated with an off\u2010resonance, low\u2010power radio\u2010frequency pulse applied during the interpulse delay period of a gradient\u2010echo partial\u2010saturation sequence (TR msec\/TE msec = 200\/20). Images in the presence and absence of the MTC pulse were concurrently acquired before and after injection of gadopen\u2010tetate dimeglumine at a dose of 0.1 mmol\/kg. The contrast agent enhanced 27 of 28 tumors. Application of the MTC pulse improved the contrast\u2010to\u2010noise ratio (C\/N) between tumor and normal white matter in 26 of 28 cases on the preinjection images and in 25 of 28 cases on the postinjection images. On the gadolinium\u2010enhanced images, the mean C\/N was 2.6 \u00b1 1.7 without the MTC pulse and 3.2 \u00b1 1.9 with the MTC pulse. The greatest contrast improvement with the MTC technique was obtained in tumors showing the strongest paramagnetic enhancement. The results indicate that MTC can improve contrast between normal brain and some intracranial neoplasms. The use of gadopentetate dimeglumine generally intensified this effect.<\/jats:p>","DOI":"10.1002\/jmri.1880020408","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T02:05:33Z","timestamp":1173146733000},"page":"401-406","source":"Crossref","is-referenced-by-count":33,"title":["Gadolinium\u2010enhanced magnetization transfer contrast imaging of intracranial tumors"],"prefix":"10.1002","volume":"2","author":[{"given":"Timo J. 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