{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:20Z","timestamp":1761058640808},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4649,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical efficacy and safety of gadopentetate dimeglumine as a paramagnetic contrast agent for magnetic resonance (MR) imaging of the extracranial head and neck was evaluated in a multicenter trial involving 60 patients. Patients with signs and\/or symptoms of a tumor in the nasopharynx, oropharynx, hypopharynx, larynx, or neck were studied. T1\u2010weighted images were obtained before and after injection of gadopentetate dimeglumine, 0.1 mmol\/kg, at a rate of 10 mL\/min. No lesions were seen on the pre\u2010 or postinjection images of five of the 60 patients. Postinjection lesion enhancement was present in 53 of the remaining 55 (96%) patients. The absence of postinjection lesion enhancement in one of the two remaining patients was useful information. Postinjection impressions differed from preinjection diagnosis in 22 of 60 (37%) patients. Additional information was obtained from postinjection relative to preinjection images in 38 of 60 (63%) patients. Four adverse experiences were reported in three of 60 (5%) patients. Two mild (chest wall pain and headache) and one moderate (nausea) adverse experiences were considered by the authors to be unrelated to the studied drug. One severe adverse experience was reported. This patient had a seizure, considered by the investigator to be remotely related to the study drug and attributed to the abrupt withdrawal of anticonvulsant medications. The data indicate that gadopentetate dimeglumine is safe and efficacious in the evaluation of patients with extracranial head and neck lesions.<\/jats:p>","DOI":"10.1002\/jmri.1880030209","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T02:55:24Z","timestamp":1173149724000},"page":"345-349","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of gadopentetate dimeglumine in the evaluation of patients with a suspected tumor of the extracranial head and neck"],"prefix":"10.1002","volume":"3","author":[{"given":"Patricia A.","family":"Hudgins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen D.","family":"Elster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val M.","family":"Runge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciska K.","family":"Kashanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold A.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.1.3763886"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(88)90527-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800130062006"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.164.3.3615884"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.1.2152985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198603000-00010"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.152.3.6463254"},{"key":"e_1_2_1_9_2","first-page":"199","article-title":"Invasion of laryngeal cartilage by cancer: comparison of CT and MR imaging","volume":"166","author":"Castelijns JA","year":"1987","journal-title":"Radiology"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100402"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870110069008"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.11.3.1852933"},{"key":"e_1_2_1_13_2","first-page":"187","article-title":"Tumors of the nasopharynx and adjacent areas: MR imaging with Gd\u2010DTPA","volume":"11","author":"Vogl T.","year":"1990","journal-title":"AJNR"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.1.2740499"},{"key":"e_1_2_1_15_2","first-page":"967","article-title":"Multicenter study of gadopentetate dimeglumine as an MR contrast agent: evaluation in patients with spinal tumors","volume":"11","author":"Sze G","year":"1990","journal-title":"AJNR"},{"key":"e_1_2_1_16_2","first-page":"53","article-title":"Multicenter double\u2010blind placebo\u2010controlled study of gadopentetate dimeglumine as an MR contrast agent: evaluation in patients with cerebral lesions","volume":"10","author":"Russell EJ","year":"1989","journal-title":"AJNR"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.1.2403679"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.173.1.2781014"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.1880030209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.1880030209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:02:19Z","timestamp":1698192139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.1880030209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1002\/jmri.1880030209"],"URL":"https:\/\/doi.org\/10.1002\/jmri.1880030209","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}