{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:23Z","timestamp":1761058643412},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enhancing effect of gadolinium diethylenetriam\u2010inepentaacetic acid (DTPA) polylysine (a macromolecular paramagnetic contrast agent) in time\u2010of\u2010flight magnetic resonance (MR) angiography of isolated perfused sheep lungs was studied. Unilateral lung damage was induced with hydrochloric acid in eight sheep. The heart and lungs were removed from the thoracic cavity, and after cannulation of the trachea and both ventricles, pulsatile perfusion and ventilation were initiated. The heart\u2010lung preparations were placed in the head coil of a 1.5\u2010T imager. Time\u2010of\u2010flight pulmonary MR angiography was performed during respiratory arrest, before and after administration of 0.02 mmol\/kg Gd\u2010DTPA\u2010polylysine. On the postcontrast angiograms, the signal intensity increased by 120% in pulmonary arteries (<jats:italic>P<\/jats:italic> &lt;.01). The contrast\u2010to\u2010noise ratio between pulmonary arteries and parenchyma increased significantly (<jats:italic>P<\/jats:italic> &lt;.01). The number of visualized generations of pulmonary artery branches increased from four to six in normal lungs and from three to five in edematous lungs. Low\u2010dose Gd\u2010DTPA\u2010polylysine significantly improves the conspicuity of the pulmonary vascular tree in time\u2010of\u2010flight pulmonary MR angiography.<\/jats:p>","DOI":"10.1002\/jmri.1880040338","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T03:20:21Z","timestamp":1173151221000},"page":"473-476","source":"Crossref","is-referenced-by-count":22,"title":["Gd\u2010DTPA\u2010polylysine\u2014enhanced pulmonary time\u2010of\u2010flight MR angiography"],"prefix":"10.1002","volume":"4","author":[{"given":"Johannes 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