{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:53:47Z","timestamp":1791046427121,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to investigate the effects of contrast agents on MR images of balloon\u2010injured carotid arteries containing atherosclerotic\u2010like lesions. We have evaluated an intravascular contrast agent, MS\u2010325 (METASYN INC., Cambridge, MA) and an extra\u2010vascular contrast agent, Optimark, (Mallinckrodt Medical Inc., St. Louis, MO) on MR angiograms obtained 4 weeks after balloon hyperinflation\u2010induced injury of the left common carotid artery in 12 hypercholesterolemic minipigs. High in\u2010plane resolution (.8 \u00d7 .4 mm<jats:sup>2<\/jats:sup>), thin slice (1 mm) time\u2010of\u2010flight gradient echo sequences were used to acquire the MR angiographic images. Vascular lumen definition was compared before and after a single bolus intravenous injection of a contrast agent. Digital subtraction angiograms were obtained from all pigs after MR imaging. High grade stenosis developed in 1 of the 12 pigs and five pigs had complete occlusion of the injured vessel. The remaining pigs exhibited essentially no visible stenoses as assessed either by MR angiography or digital subtraction angiography. The vessel walls of the stenosed and occluded vessels were visible after the injection of either intravascular or extravascular contrast agent. Histologic analyses showed well developed neovascularization in the neointima or occlusive thrombosis. We conclude that the observed contrast\u2010enhanced vessel wall is caused by an increased vascular supply associated with thrombosis and neointimal thickening that leads to an accumulation of contrast agent in the abnormal vessel walls after the injection of the T1\u2010shortening paramagnetic contrast agent.<\/jats:p>","DOI":"10.1002\/jmri.1880070128","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T03:35:54Z","timestamp":1173929754000},"page":"183-190","source":"Crossref","is-referenced-by-count":57,"title":["Contrast\u2010enhanced magnetic resonance angiography of carotid arterial wall in pigs"],"prefix":"10.1002","volume":"7","author":[{"given":"Weili","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana R.","family":"Abendschein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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