{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:39:37Z","timestamp":1760981977910},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of our research was to determine the effects of superparamagnetic iron oxide on MR imaging of the portal venous system. Eight piglets were examined in deep anaesthesia and respiratory arrest using a time\u2010of\u2010flight magnetic resonance fast low angle shot, two\u2010dimensional angiography sequence at 1.5T. MR angiograms were acquired precontrast and after intravenous administration of a cumulative dose of 10, 20 and 40 \u03bcmol\/kg SHU 555A, a superparamagnetic iron oxide contrast agent for MR imaging with a particle size of 60 nm. For each dose, two subsequent sets of scans were obtained and reconstructed by a maximum\u2010intensity\u2010projection algorithm. Hepatic parenchymal and portal venous signal intensities were measured, and portal vein contrast calculated for each set of scans. All examinations were visually rated as to portal vein contrast and homogeneity by two blinded observers. Receiver operating characteristics of both observers were analyzed. The contrast agent reduced hepatic parenchymal signal in a dose\u2010dependent way. After a cumulative dose of 10 \u03bcmol iron oxide, hepatic parenchymal signal intensity decreased to 63 \u00b1 6% (average of measurements at 4 and 14 minutes, mean \u00b1 standard error of the mean), after 20 \u03bcmol to 24 \u00b1 3%, and after 40 \u03bcmol to 12 \u00b1 1% of control. Intra\u2010vascular signal in the left main portal vein branch increased to 117 \u00b1 6%, 127 \u00b1 10%, and 133 \u00b1 9% of control, respectively. The contrast\u2010to\u2010noise ratio of the portal vein improved (521 \u00b1 90%, 891 \u00b1 178%, and 995 \u00b1 201% of control in the left portal vein main branch). Intravascular signal intensities increased slightly. The combined effect improved contrast of the portal vein stem and its branches. Receiver operating characteristics analysis documented dose\u2010dependency of contrast medium effects on portal venous contrast and intravascular homogeneity. Visual rating also indicated a positive effect on portal venous contrast. The superparamagnetic iron oxide agent improved portal venous contrast with surrounding hepatic parenchyma in this normal animal model, and could potentially result in more accurate diagnosis of portal venous pathology.<\/jats:p>","DOI":"10.1002\/jmri.1880070129","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T03:35:35Z","timestamp":1173929735000},"page":"191-196","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of portal MR angiography using superparamagnetic iron oxide"],"prefix":"10.1002","volume":"7","author":[{"given":"F. D.","family":"Knollmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"B\u00f6ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Teltenk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wlodarczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"M\u00fchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th. J.","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040500"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.1.2006289"},{"key":"e_1_2_1_4_2","first-page":"305","volume-title":"Magnetic resonance angiography: concepts and applications","author":"Marchal G","year":"1993"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-66-783-214"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880040338"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1032431"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.2.7617863"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.2.7617864"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972804"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972805"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90470-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.1.8273667"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230114"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198609000-00009"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972790"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199406001-00029"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.5.7717222"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880030414"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0033-8389(22)00304-9","article-title":"Presurgical evaluation of the liver transplant candidate","volume":"33","author":"Ferris JV","year":"1995","journal-title":"Radiol Clin North Am"},{"key":"e_1_2_1_21_2","first-page":"271","article-title":"Portal magnetic resonance angiography","volume":"1","author":"Finn JP","year":"1993","journal-title":"MRI Clin North Am"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.2.8475282"},{"key":"e_1_2_1_23_2","first-page":"15","volume-title":"Hepatobiliary MRI","author":"Mitchell DG","year":"1992"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.1880070129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.1880070129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T22:11:41Z","timestamp":1698444701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.1880070129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1002\/jmri.1880070129"],"URL":"https:\/\/doi.org\/10.1002\/jmri.1880070129","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}