{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:19:20Z","timestamp":1758633560786},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":2757,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purposes of this study were (\u03b1) to determine the prevalence of bone marrow abnormalities in patients with chronic lymphocytic leukemia (CLL) using quantitative MR assessment of axial marrow composition and peripheral marrow distribution; (<jats:italic>b<\/jats:italic>) to assess the agreement between both quantitative MR methods and compare their sensitivities to detect marrow alterations; and (<jats:italic>c<\/jats:italic>) to correlate MR findings with clinical and laboratory parameters. Twenty\u2010nine consecutive patients with biopsy\u2010proven CLL were investigated on a .5\u2010T MR imager to determine bulk T1 relaxation times of the vertebral bone marrow and proportion of proximal femur surface area occupied by nonfatty marrow on coronal T1\u2010weighted MR images of one hip. Of the 29 patients, 12 (41%) had abnormal increase in lumbar marrow T1 values (&gt;600 msec) and 16 (55%) had increased proportion of surface area occupied by non\u2010fatty marrow in the proximal femur (&gt;+1 SD compared to normal values determined in sex\u2010 and age\u2010matched healthy subjects). The results of both quantitative MR methods were normal in 12 patients and abnormal in 11 patients (agreement, 79%). Patients with alterations in peripheral marrow distribution had significantly higher T1 relaxation times (<jats:italic>P<\/jats:italic> = .001) than those with normal peripheral marrow. Patients with abnormal marrow composition or distribution at MRI had significantly higher blood and marrow lymphocytosis than patients without these features. In conclusion, the agreement between both quantitative MR methods suggests a parallelism between changes in axial marrow composition and in peripheral marrow distribution in patients with CLL. The limits of quantitative MRI in CLL must be kept in mind, because quantitative MR methods failed to detect leukemic marrow infiltration in 41% of patients.<\/jats:p>","DOI":"10.1002\/jmri.1880080333","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T14:36:02Z","timestamp":1174055762000},"page":"733-739","source":"Crossref","is-referenced-by-count":17,"title":["Chronic lymphocytic leukemia: Changes in bone marrow composition and distribution assessed with quantitative MRI"],"prefix":"10.1002","volume":"8","author":[{"given":"Frederic E.","family":"Lecouvet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno C. 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