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HIE was induced in neonatal rabbits by a combination of common carotid artery (CCA) ligation and hypoxia. Serial diffusion and perfusion\u2010weighted magnetic resonance images were acquired before, during, and after the hypoxic interval. Focal areas of decreased apparent diffusion coefficient (ADC) were detected initially in the cortex ipsilateral to CCA ligation within 62 \u00b1 48 min from the onset of hypoxia. Subsequently, these areas of decreased ADC spread to the subcortical white matter, basal ganglia (ipsilateral side), and then to the contralateral side. Corresponding perfusion\u2010weighted images showed relative cerebral blood volume deficits which closely matched those regions of ADC change. Our results show that MRI diffusion and perfusion\u2010weighted imaging can detect acute cell swelling post\u2010hypoxia in this HIE model.<\/jats:p>","DOI":"10.1002\/jmri.1880080411","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:01:25Z","timestamp":1174521685000},"page":"820-828","source":"Crossref","is-referenced-by-count":29,"title":["Diffusion and perfusion magnetic resonance imaging of the evolution of hypoxic ischemic encephalopathy in the neonatal rabbit"],"prefix":"10.1002","volume":"8","author":[{"given":"Helen E.","family":"D'Arceuil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"de Crespigny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"R\u00f6ther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemi","family":"Seri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rhine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000240079"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.152.2.6739805"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198008000-00005"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30894-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.2.3550882"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83323-2"},{"issue":"4","key":"e_1_2_1_8_2","first-page":"375","article-title":"Prospective observations of 100 high\u2010risk neonates by high\u2010field (1.5 Tesla) magnetic resonance imaging of the central nervous system. 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