{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:00Z","timestamp":1772994960244,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T00:00:00Z","timestamp":1087776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Norwegian SIDS Society"},{"name":"AGA AB Medical Research Fund"},{"DOI":"10.13039\/501100004102","name":"Laerdal Foundation for Acute Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004102","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Abbot Norge AS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the utility of functional and morphological magnetic resonance imaging (MRI) to assess the extent of brain injury in a hypoxia\u2010ischemia (HI) piglet model and further to validate that the desired ischemic injury was successfully induced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>MRI was performed at 1.5 T in anesthetized piglets (<jats:italic>N<\/jats:italic> = 10, age = 12\u201036 hours). Relative cerebral blood flow (rCBF), time\u2010to\u2010peak (TTP) contrast, and apparent diffusion coefficient (ADC) were estimated at different time points pre\u2010, during, and post\u2010HI. The effect following bilateral clamping of the carotid arteries was assessed by contrast\u2010enhanced MR angiography (MRA) and phase contrast MR angiography (PCA) (<jats:italic>N<\/jats:italic> = 4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A linear correlation was observed between relative cerebral perfusion reduction and cerebral ADC during HI (r<jats:sup>2<\/jats:sup> = 0.85, <jats:italic>P<\/jats:italic> &lt; 0.05). There was no correlation between rCBF reduction during 30 minutes of HI and cerebral ADC after 30 or 150 minutes of reperfusion\/reoxygenation (RR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of morphological and functional (perfusion and diffusion) MRI enabled consistent assessment of both the presence and absence of complete occlusion as well as the functional significance of the occlusion. J. Magn. Reson. Imaging 2004;20:8\u201315. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20084","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T16:03:45Z","timestamp":1087833825000},"page":"8-15","source":"Crossref","is-referenced-by-count":12,"title":["Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model"],"prefix":"10.1002","volume":"20","author":[{"given":"Berit H.","family":"Munkeby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Lyng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahn Frederik","family":"Fr\u00f8en","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldrid H.","family":"Winther\u2010Larssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Henrik","family":"Rosland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010J\u00f8rgen","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atle","family":"Bj\u00f8rnerud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047112"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2001.0039"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000072998.70087.E9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39599"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080411"},{"key":"e_1_2_7_7_2","volume-title":"Swine in biomedical research","author":"Tumbleson M","year":"1986"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1967.0002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00361-8"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02700-2"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200116060-00011"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(200005)11:5<488::AID-JMRI4>3.0.CO;2-V"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10066"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.70.829.9059290"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10058"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.2.2217777"},{"key":"e_1_2_7_17_2","unstructured":"BjornerudA.The ICE software package: direct and accurate co\u2010registration of anatomical and functional datasets using DICOM image geometry information. 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