{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:21:09Z","timestamp":1791973269951,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T00:00:00Z","timestamp":1087776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the potential role of micro\u2010magnetic resonance imaging (\u03bc\u2010MRI) for quantifying trabecular and cortical bone structural parameters in renal osteodystrophy (ROD), a multifactorial disorder of bone metabolism, traditionally evaluated by bone biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Seventeen hemodialysis patients (average PTH level = 502 \u00b1 415 \u03bcg\/liter) were compared with 17 age\u2010, gender\u2010, and body mass index (BMI)\u2010matched control subjects. The average dialysis duration for the patients was 5.5 years (range = 0.96\u201018.2 years). Three\u2010dimensional (3D) fast large\u2010angle spin\u2010echo (FLASE) MR images of the distal tibia (voxel size = 137 \u00d7 137 \u00d7 410 \u03bcm<jats:sup>3<\/jats:sup>) were processed to yield bone volume fraction (BV\/TV). From a skeletonized representation of the trabecular bone network, the topology of each bone voxel was determined providing surface and curve voxel densities (SURF and CURV) and the topological erosion index (EI). Further, high\u2010resolution two\u2010dimensional (2D) spin\u2010echo images were collected at the tibial midshaft for measurement of cortical bone cross\u2010sectional area (CCA), relative CCA expressed as a percentage of total bone area (RCA), and mean cortical thickness (MCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data show both RCA and MCT to be lower in the patients (61.2 vs. 69.1%, <jats:italic>P<\/jats:italic> = 0.008, and 4.53 vs. 5.19 mm, <jats:italic>P<\/jats:italic> = 0.01). BV\/TV and SURF were lower, while EI was increased in the patients, although these differences were not quite significant (<jats:italic>P<\/jats:italic> = 0.06\u20100.09). All of the cortical and trabecular findings are consistent with increased bone fragility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that \u03bc\u2010MRI may have potential to characterize the structural implications of metabolic bone disease, potentially providing a noninvasive tool for the evaluation of therapies for ROD. J. Magn. Reson. Imaging 2004;20:83\u201389. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20085","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T16:04:31Z","timestamp":1087833871000},"page":"83-89","source":"Crossref","is-referenced-by-count":103,"title":["Quantitative high\u2010resolution magnetic resonance imaging reveals structural implications of renal osteodystrophy on trabecular and cortical bone"],"prefix":"10.1002","volume":"20","author":[{"given":"Felix W.","family":"Wehrli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punam K.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon 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