{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:36:39Z","timestamp":1790940999980,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T00:00:00Z","timestamp":1098403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the benefit of using higher field strengths for BOLD MRI to detect changes in renal medullary oxygenation following pharmacological maneuvers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Renal BOLD MRI, primarily at 1.5T, has been shown to be useful for monitoring changes in medullary oxygenation status. We performed the present studies on a 3.0T scanner using a multiple gradient\u2010echo (mGRE) sequence with a multicoil array to acquire 16 T<jats:sub>2<\/jats:sub>*\u2010weighted images within a single breath\u2010hold. Data were obtained before and after administration of furosemide (20 mg iv).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline renal R<jats:sub>2<\/jats:sub>* (mean \u00b1 SE) at 3.0T was 37.4\u00b11.2 Hz in the medulla, and 21.8 \u00b1 1.2 Hz in the cortex. The BOLD response to furosemide (\u0394R2*) at 3.0T was 11.8 \u00b1 1.1 Hz in the medulla, and 3.0 \u00b1 0.5 Hz in the cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher magnetic field strength is beneficial for renal BOLD MRI studies. The cortico\u2010medullary contrast on the R<jats:sub>2<\/jats:sub>* map was significantly improved at 3.0T, with no evidence of increased bulk susceptibility artifacts. Baseline R<jats:sub>2<\/jats:sub>* and \u0394R<jats:sub>2<\/jats:sub>* in the renal medulla at 3.0T were both significantly higher compared to our previously reported data obtained at 1.5T. J. Magn. Reson. Imaging 2004;20:901\u2013904. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20176","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T16:33:01Z","timestamp":1098462781000},"page":"901-904","source":"Crossref","is-referenced-by-count":55,"title":["Evaluation of intrarenal oxygenation by BOLD MRI at 3.0T"],"prefix":"10.1002","volume":"20","author":[{"given":"Lu\u2010Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda S.Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Dunkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pottumarthi V.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113612"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199212007-00021"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.663"},{"key":"e_1_2_6_5_2","first-page":"597","article-title":"The role of medullary ischemia in acute renal failure","volume":"3","author":"Heyman SN","year":"1995","journal-title":"New Horiz"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.575"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070633"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00237.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3271"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00057.x"},{"key":"e_1_2_6_11_2","first-page":"343","volume-title":"Magnetic resonance imaging physical principles and sequence design","author":"Haacke E","year":"1999"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910030413"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(93)81441-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910170206"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1081"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910380220"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20043"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321006"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10196"},{"key":"e_1_2_6_20_2","first-page":"1727","article-title":"Multivoxel 3D proton spectroscopy in the brain at 1.5 versus 3.0 T: signal\u2010to\u2010noise ratio and resolution comparison","volume":"22","author":"Gonen O","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290126"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.20176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.20176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T15:33:31Z","timestamp":1697124811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.20176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,22]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/jmri.20176"],"URL":"https:\/\/doi.org\/10.1002\/jmri.20176","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,22]]}}}