{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:04:52Z","timestamp":1791187492549,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine if the diffusion tensor imaging (DTI) parameters fractional anisotropy (FA) and mean diffusivity (MD) can differentiate between accompanying edema and tumor cell infiltration of white matter (WM) beyond the tumor edge as defined from conventional MRI in low\u2010 and high\u2010grade gliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We examined 12 patients with high\u2010grade gliomas\/glioblastomas and eight patients with low\u2010grade gliomas and compared them to 10 patients with meningiomas, in which no tumor infiltration is expected. The tumor was defined as the enhancing area in glioblastomas and meningiomas and as the area of increased T2\u2010signal in low\u2010grade gliomas. FA and MD were measured in the center of the tumor and in the adjacent WM. The contralateral WM and internal capsule were used as an internal standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing the WM areas of increased T2\u2010signal adjacent to meningiomas and glioblastomas, we saw a trend (without significance) towards a reduction of FA, but not of MD, in glioblastomas. We found no changes of FA and MD in the WM adjacent to low\u2010grade gliomas (without T2\u2010signal increase) compared to the WM of the contralateral hemisphere. In meningiomas and high\u2010grade gliomas\/glioblastomas, a narrow rim of significantly (<jats:italic>P<\/jats:italic> &lt; 0.01) increased FA and decreased MD values around the enhancing tumor area was seen, whereas in low\u2010grade gliomas, such a rim could not be defined. There was no contribution of FA or MD to grading of gliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In glioblastomas, a reduction of FA in the edematous area surrounding the tumor may indicate tumor cell infiltration, but a reliable differentiation between infiltration and vasogenic edema is not yet possible on the basis of DTI. The additional finding of a narrow rim of increased FA and decreased MD at the edge of glioblastomas (as well as in meningiomas) may be caused by com\u2010pressed WM fibers and\/or increased vascularity, but does not contribute to exclude peripheral cellular infiltration. J. Magn. Reson. Imaging 2004;20:905\u2013912. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20217","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T22:51:02Z","timestamp":1100904662000},"page":"905-912","source":"Crossref","is-referenced-by-count":117,"title":["Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas"],"prefix":"10.1002","volume":"20","author":[{"given":"A.","family":"Tropine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vucurevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Delani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stoeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050450"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050726"},{"key":"e_1_2_5_4_2","first-page":"969","article-title":"Diffusion\u2010weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings","volume":"22","author":"Stadnik TW","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_5_2","first-page":"1081","article-title":"The role of diffusion\u2010weighted imaging in patients with brain tumors","volume":"22","author":"Kono K","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_6_2","first-page":"65","article-title":"Appearances of meningiomas on diffusion\u2010weighted images: correlation diffusion constants with histopathologic findings","volume":"22","author":"Filippi CG","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.24.2029"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199901)9:1<53::AID-JMRI7>3.0.CO;2-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<2::AID-MRM2>3.0.CO;2-Y"},{"key":"e_1_2_5_10_2","first-page":"60","article-title":"Apparent diffusion coefficients in the evaluation of high\u2010grade cerebral gliomas","volume":"22","author":"Castillo \u00cc","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2001.0741"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.3.8109520"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.3.r99au51770"},{"key":"e_1_2_5_14_2","first-page":"534","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"LeBihan D","year":"2001","journal-title":"J Magn Reson"},{"key":"e_1_2_5_15_2","unstructured":"ChepuriNB YenY RiedyG BurdetteJ.Alteration of diffusion anisotropy in patients with intracranial tumors. 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