{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:55:23Z","timestamp":1761101723859,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T00:00:00Z","timestamp":1113523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["RO1 HL51146","R43 HL58285"],"award-info":[{"award-number":["RO1 HL51146","R43 HL58285"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate that contrast\u2010enhanced MRI (ceMRI) with the aid of Gd(ABE\u2010DTTA) is able to detect ischemic events in the heart in a canine ischemia\/reperfusion (30\/40 minutes) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>ECG\u2010gated, T1\u2010weighted MR image sets (four to five slices each) with three\u2010minute time resolution were collected in transiently LAD\u2010occluded dogs. Following the acquisition of control image sets, ischemia was started by occluding the LAD. Either Gd(ABE\u2010DTTA) (<jats:italic>N<\/jats:italic> = 6) or Gd(DTPA) (<jats:italic>N<\/jats:italic> = 6) was injected, and imaging was continued for 30 minutes of ischemia and 40 minutes of reperfusion. The contrast agent (CA)\u2010induced MRI signal intensity enhancement (SIE) and contrast were monitored. Microspheres measured myocardial perfusion (MP) to verify areas of ischemia and reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SIEs of 86% \u00b1 3% and 97% \u00b1 3% in nonischemic, and 25% \u00b1 5% and 29% \u00b1 8% in ischemic regions were found within three minutes of onset of ischemia with Gd(ABE\u2010DTTA) and Gd(DTPA), respectively. For the rest of the 30 minutes of ischemia, with Gd(ABE\u2010DTTA) SIE of 60% \u00b1 3% and 25% \u00b1 5% persisted in the nonischemic and ischemic regions, respectively. With Gd(DTPA), however, SIE in the nonischemic areas decreased rapidly after the first three minutes of ischemia, while SIE in the ischemic areas increased, abolishing contrast. Thus, there was a persistent contrast with Gd(ABE\u2010DTTA) and a short\u2010lived contrast with Gd(DTPA) during ischemia. Furthermore, with Gd(ABE\u2010DTTA) some contrast was still visible in the early reperfusion period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gd(ABE\u2010DTTA) in an ischemia\/reperfusion model induces a persistent MRI contrast between regions of normal and ischemic myocardium, and verifies reperfusion. Therefore, it can be used to detect myocardial ischemic events. J. Magn. Reson. Imaging 2005;21:536\u2013545. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20326","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T20:47:19Z","timestamp":1113598039000},"page":"536-545","source":"Crossref","is-referenced-by-count":10,"title":["Gd(ABE\u2010DTTA)\u2010enhanced cardiac MRI for the diagnosis of ischemic events in the heart"],"prefix":"10.1002","volume":"21","author":[{"given":"Tam\u00e1s","family":"Simor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Gaszner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Oshinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Waldrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderic I.","family":"Pettigrew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n G.","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Hild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel A.","family":"Elgavish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600502"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0202.102016"},{"key":"e_1_2_6_4_2","first-page":"285","article-title":"Contrast agents for cardiovascular magnetic resonance imaging. 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