{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:43:57Z","timestamp":1791179037577,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T00:00:00Z","timestamp":1121644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the influence of isoflurane and pentobarbital anesthesia and the carrier gases on myocardial blood flow (MBF) in the rat heart in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>MBF was quantified in vivo using arterial spin\u2010labeling (ASL) magnetic resonance imaging (MRI). Left ventricular (LV) function was estimated during the same experiment using cine\u2010MRI. Thirty\u2010four male Wistar\u2010Kyoto rats were divided in four groups, one anesthetized with isoflurane in oxygen:nitrous oxide mix (ISO), the three others with intraperitoneal pentobarbital, and breathing either room air (PB), oxygen:nitrous oxide (PB + N<jats:sub>2<\/jats:sub>O), or oxygen:nitrogen (PB + N<jats:sub>2<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MBF was significantly higher in the ISO and PB + N<jats:sub>2<\/jats:sub>O groups vs. PB and in ISO vs. PB + N<jats:sub>2<\/jats:sub>, with the following respective MBF values: ISO, 5.9 \u00b1 1.1; PB, 4.0 \u00b1 0.8; PB + N<jats:sub>2<\/jats:sub>O, 5.1 \u00b1 1.4; and PB + N<jats:sub>2<\/jats:sub>, 4.6 \u00b1 0.8 mL\/g\/minute, mean \u00b1 SD. Ejection fractions were reduced by 10% in PB and PB + N<jats:sub>2<\/jats:sub>O rats vs. ISO rats. Cardiac output (CO) and index (CI) were 25 to 30% lower in all rats anesthetized with pentobarbital than with isoflurane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Isoflurane and nitrous oxide induce a higher MBF than pentobarbital. Isoflurane also induces a higher ejection fraction in healthy rats. J. Magn. Reson. Imaging 2005;22:242\u2013247. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20352","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T19:47:05Z","timestamp":1121716025000},"page":"242-247","source":"Crossref","is-referenced-by-count":51,"title":["In vivo assessment of myocardial blood flow in rat heart using magnetic resonance imaging: Effect of 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