{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:26:45Z","timestamp":1791156405849,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t\u2010PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 42 patients with hemispheric stroke were recruited for a thrombolytic study. Intravenous t\u2010PA was given after MRI within the first seven hours after stroke onset. Volumes were evaluated on day 0 and day 1 with diffusion\u2010weighted imaging (DWI), on day 60 with T2\u2010weighted imaging (T2WI), and recanalization was assessed based on day 1 MR angiography (MRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lesion volume increased between day 0 and day 1, and decreased between day 1 and day 60. It was lower in the group of patients with recanalization on day 1 MRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Volume analysis emphasizes the effectiveness of recanalization as a predictive factor for better outcome, based on final infarct size. The decrease in lesion volumes between day 1 and day 60 suggests that other factors leads to overestimation of day 1 abnormal diffusion volume. This could explain the delayed partial reversibility of the DWI abnormality. J. Magn. Reson. Imaging 2005;22:23\u201328. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20363","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T16:34:55Z","timestamp":1119371695000},"page":"23-28","source":"Crossref","is-referenced-by-count":23,"title":["Evolution of lesion volume in acute stroke treated by intravenous 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