{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:41Z","timestamp":1786978181228,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T00:00:00Z","timestamp":1121644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To measure the proton magnetization transfer ratio (MTR) maps in control and collagen\u2010depleted bovine patellar cartilage specimens as a function of cartilage depth during mechanical compression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>One\u2010dimensional proton projection MR images employing a spin\u2010echo imaging sequence were obtained on a custom\u2010built NMR spectrometer interfaced to an Oxford magnet operating at 2T. The mechanical compressions were performed with a custom\u2010built MR\u2010compatible pressure cell and evaluated dynamically via one\u2010dimensional projection. High\u2010spatial\u2010resolution two\u2010dimensional MT images were obtained using a fast spin\u2010echo (FSE) sequence on a 4T whole\u2010body GE Signa scanner (GEMS, Milwaukee, WI, USA) to quantify the MTR maps of normal and collagen\u2010depleted bovine patellae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All of the cartilage plugs from the bovine patellae showed that the MTR value increases continuously as a function of cartilage depth. Although the overall MTR trend as a function of depth is the same in both control and collagen\u2010depleted cartilage, the magnitude of the MTR value differs between the two. The MTR value is decreased with collagen depletion and increased with mechanical compression. The increase in MTR value during compression may be due to a decrease in free water content and volume, resulting in an increase in collagen concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated that the MTR in bovine patellar cartilage is depth\u2010dependent and is relatively higher in the radial zone compared to the superficial zone. The high MTR in the radial zone not only depends on collagen content, it may also reflect a number of other parameters, such as the arrangement of macromolecules, high solid content, bound water fraction attached to macromolecules, radial orientation, etc. J. Magn. Reson. Imaging 2005;22:318\u2013323. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.20377","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T15:46:42Z","timestamp":1121701602000},"page":"318-323","source":"Crossref","is-referenced-by-count":25,"title":["Depth\u2010dependent proton magnetization transfer in articular cartilage"],"prefix":"10.1002","volume":"22","author":[{"given":"Ravinder R.","family":"Regatte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarma V.S.","family":"Akella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340307"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290209"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110402"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(01)00433-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(97)90012-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199905)9:5<653::AID-JMRI6>3.0.CO;2-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1131"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199910)10:4<527::AID-JMRI5>3.0.CO;2-0"},{"key":"e_1_2_6_10_2","unstructured":"FaberSC HerberholdC StammbergerT ReiserM EnglmeierKH EcksteinF.Quantitative changes of articular cartilage microstructure during compression of an intact joint. In: Proceedings of the 7th Annual Meeting of ISMRM Philadelphia 1999. p547."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10305"},{"key":"e_1_2_6_12_2","first-page":"1","article-title":"Degenerative joint disease","volume":"47","author":"Buckwalter JA","year":"1995","journal-title":"Clin Symp"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200010000-00008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.2.121"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108676"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.20377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.20377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T18:24:11Z","timestamp":1697135051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.20377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,18]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1002\/jmri.20377"],"URL":"https:\/\/doi.org\/10.1002\/jmri.20377","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,18]]}}}