{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:07:31Z","timestamp":1761988051249},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T00:00:00Z","timestamp":1124150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the differences between macromolecular and small molecular contrast agents in interstitial magnetic resonance (MR) lymphography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In two groups of rabbits (<jats:italic>N<\/jats:italic> = 12 each), 0.5\u2010mL volumes of 0.5 M and 0.1 M gadodiamide, respectively, were injected subcutaneously into the dorsal feet of both hind legs. After a 24\u2010hour interval, 0.5 mL of Gd [DTPA\u2010bis (2\u2010aminoethoxy) ethane] polymeric contrast agent (Gd\u2010poly\u2010DTPA\u2010EOEA) injection (0.1 M) was injected into the same sites in each rabbit. T1\u2010weighted three\u2010dimensional gradient\u2010echo and maximum intensity projection (MIP) images were obtained before and after the administration of each agent. The nodal maximum short\u2010axis diameter (MSAD) and signal\u2010to\u2010noise ratio (SNR) at each time point were measured. Postmortem measurements of nodal MSADs were also performed. The nodal MSAD measurements obtained by MR lymphography were compared with the postmortem measurements. As an additional control experiment, six rabbits received a subcutaneous injection of 0.5 mL of 0.1 M gadodiamide at the same sites as those described above. This procedure was repeated after a 24\u2010hour interval to determine whether the first injected gadodiamide had any effect on the performance of the subsequently injected agent, by comparing the differences in nodal MSADs obtained by MR lymphography after each injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gd\u2010poly\u2010DTPA\u2010EOEA showed a significantly longer enhancement plateau compared to gadodiamide. In comparison with postmortem measurements, nodal measurements by MR lymphography with Gd\u2010poly\u2010DTPA\u2010EOEA at the peak\u2010enhancement phase revealed no significantly different MSADs (<jats:italic>P<\/jats:italic> &gt; 0.05), whereas nodal measurements by MR lymphography with gadodiamide showed significantly smaller MSADs (<jats:italic>P<\/jats:italic> &lt; 0.05). A comparison of the nodal MSADs measured in two gadodiamide\u2010enhanced MR examinations after the 24\u2010hour interval showed no significant difference (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interstitial MR lymphography with polymeric Gd\u2010poly\u2010DTPA\u2010EOEA enhancer enables more sufficient and reliable visualization of lymph nodes compared to small molecular gadodiamide. J. Magn. Reson. Imaging 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20395","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T15:47:18Z","timestamp":1124207238000},"page":"361-367","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Gd [DTPA\u2010bis (2\u2010aminoethoxy) ethane] polymeric contrast agent with gadodiamide injection for interstitial MR lymphography: Experimental study with 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