{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:56:59Z","timestamp":1761393419718},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether and how the blood\u2010oxygenation\u2010level\u2013dependent (BOLD) functional MRI (fMRI) signal is modified by brain tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The BOLD signal depends on the perfusion, which in turn may be affected in the presence of a tumor. Some studies have demonstrated a reduced BOLD signal in the tumor\u2010bearing hemisphere. The BOLD signal variation in the motor cortex area was studied with finger tapping in a brain tumor group and a control group. An a priori volume\u2010of\u2010interest (VOI)\u2010based method was applied that allows quantification of the mean BOLD signal amplitude and extent of activated volume. BOLD signal amplitude and activated volume were correlated with the extent of edema, a mass effect on the central sulcus, tumor volume, distance of tumor to somatosensory cortex, and tumor blood volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the tumor group the ipsilateral activated volume was reduced by 21% (<jats:italic>P<\/jats:italic> = 0.025) and the mean signal amplitude was reduced by 16% (<jats:italic>P<\/jats:italic> = 0.004). The mean BOLD signal amplitude shows a significant correlation with the total intratumoral blood volume (<jats:italic>P<\/jats:italic> = 0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that the peritumoral perfusion was reduced resulting due to a tumor aspirating perfusion (steal phenomenon). J. Magn. Reson. Imaging 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20530","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T16:16:35Z","timestamp":1141056995000},"page":"435-443","source":"Crossref","is-referenced-by-count":45,"title":["BOLD signal in the motor cortex shows a correlation with the blood volume of brain 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