{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:44:10Z","timestamp":1784990650574,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To ascertain the suitability of vertebrae adjacent to spinal bone lesions as a signal intensity reference on MRI, and compare the MR spectroscopic appearance of vertebral body compression fractures due to malignant tumor infiltration, bone weakening (e.g., osteoporosis), and\/or minor trauma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010five patients with spinal compression fractures underwent routine spinal MRI with an additional <jats:sup>1<\/jats:sup>H MRS study protocol to assess the percent fat fraction of the compressed vertebrae as well as the adjacent bony environment. Peak areas for water and total lipid were calculated from short\u2010TE single\u2010voxel <jats:sup>1<\/jats:sup>H MR spectra using the LCModel analyzing tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were consistent water\u2010only patterns in the fractured vertebra suggesting either near complete marrow replacement by malignant tissue or local edematous fluid\/hemorrhage within the marrow spaces. However, the adjacent vertebrae showed a wide range of patterns from a dominant lipid signal to the inverse of a pronounced water level. These results far exceed the normal variation expected based on age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that the adjacent vertebrae may not be an accurate reference, especially in diffusion\u2010weighted imaging (DWI), because of the large difference between the two compartments. Furthermore, in the case of gradient\u2010echo measurements, the in\u2010phase vs. opposed\u2010phase effects are significant. J. Magn. Reson. Imaging 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20531","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T15:16:34Z","timestamp":1141053394000},"page":"574-577","source":"Crossref","is-referenced-by-count":6,"title":["Vertebrae adjacent to spinal bone lesion are inconsistent reference markers: A magnetic resonance spectroscopic viewpoint"],"prefix":"10.1002","volume":"23","author":[{"given":"Helmut","family":"Rumpel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling Ling","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Peng","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Ai","family":"Png","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K.L.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston E.H.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,27]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"383","article-title":"Pictorial essay\u2014MR appearances of osseous spine tumors","volume":"12","author":"Lakhkar BN","year":"2002","journal-title":"Ind J Radiol Imaging"},{"key":"e_1_2_5_3_2","first-page":"165","article-title":"Characterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging","volume":"23","author":"Zhou XJ","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_4_2","first-page":"366","article-title":"Diagnostic value of increased diffusion weighting of a steady\u2010state free precession sequence for differentiating acute benign osteoporotic fractures from pathologic vertebral compression fractures","volume":"22","author":"Baur A","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.75.891.750207"},{"key":"e_1_2_5_6_2","first-page":"1489","article-title":"In reply to \u201cCharacterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging.\u201d","volume":"24","author":"Mulkern RV","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20244"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.698"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.172.2.9930819"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200102)13:2<263::AID-JMRI1038>3.0.CO;2-M"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.6.01831761"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200210010-00019"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050001"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.20531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.20531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:38:09Z","timestamp":1697294289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.20531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,27]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/jmri.20531"],"URL":"https:\/\/doi.org\/10.1002\/jmri.20531","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,27]]}}}