{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:53:10Z","timestamp":1790880790712,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T00:00:00Z","timestamp":1143072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the ability of the ultrasmall superparamagnetic iron oxide (USPIO) SHU555C vs. gadopentetate dimeglumine (Gd\u2010DTPA) to detect antigen\u2010induced monoarthritis with MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve seven\u2010week\u2010old female rats with an antigen\u2010induced monoarthritis of the right knee were randomly assigned to two groups. Animals in group I (<jats:italic>N<\/jats:italic> = 6) underwent MRI using T1\u2010weighted gradient\u2010echo sequences before injection and at 2, 9, 17, 25, 33, 40, 47, 55, and 63 minutes postinjection (p.i.) of Gd\u2010DTPA on day 1, and before injection and at 3, 23, 43, and 123 minutes p.i. of SHU555C on day 2. Animals in group II (<jats:italic>N<\/jats:italic> = 6) were imaged before injection and at 3, 23, 43, and 123 minutes p.i. using identical sequences. Signal\u2010to\u2010noise ratios (SNRs) and relative enhancement (\u0394SI%) of arthritic and normal synovium were determined from region\u2010of\u2010interest (ROI) measurements in consensus reading by two experienced radiologists. Data were tested for significant differences between the two agents and between the arthritic and normal knees using a mixed\u2010effect model and F\u2010tests (<jats:italic>P<\/jats:italic> &lt; 0.05). Joints were processed for histopathology as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>USPIO and Gd\u2010DTPA showed significant enhancement differences (<jats:italic>P<\/jats:italic> &lt; 0.001). USPIO provided a progressive and persistent enhancement of arthritic joints while Gd\u2010DTPA provided an early and rapidly declining enhancement. Maximal enhancement in synovitis was 400% at 40\u2013120 minutes p.i. of USPIO vs. 300% at two minutes p.i. of Gd\u2010DTPA. USPIO provided a significant higher difference in enhancement between the arthritic and normal synovium than Gd\u2010DTPA (<jats:italic>P<\/jats:italic> &lt; 0.001). Histopathology confirmed marked inflammatory synovial changes in all arthritis\u2010induced right knee joints and normal synovium in all left knee joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both USPIO and Gd\u2010DTPA detect arthritis by positive T1\u2010enhancement. Compared to standard Gd\u2010DTPA, the USPIO SHU555C provides a comparable maximal T1\u2010enhancement (at two minutes p.i for Gd\u2010DTPA and between 43 and 123 minutes p.i. for SHU555C), but in addition it provides a prolonged T1\u2010enhancement of synovitis and a higher difference between the relative enhancement of arthritic and normal synovium. J. Magn. Reson. Imaging 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20556","type":"journal-article","created":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T15:50:44Z","timestamp":1143129044000},"page":"720-727","source":"Crossref","is-referenced-by-count":39,"title":["MRI of arthritis: Comparison of ultrasmall superparamagnetic iron oxide vs. Gd\u2010DTPA"],"prefix":"10.1002","volume":"23","author":[{"given":"Gerhard H.","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"von Vopelius\u2010Feldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Wendland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Piontek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hsiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike E.","family":"Daldrup\u2010Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar578"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"e_1_2_6_4_2","first-page":"154","article-title":"Window of opportunity in early rheumatoid arthritis: possibility of altering the disease process with early intervention","volume":"1","author":"Quinn MA","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_5_2","first-page":"15","article-title":"Diagnosing early rheumatoid arthritis (RA). 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