{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:40:23Z","timestamp":1790080823104,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T00:00:00Z","timestamp":1160352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate the feasibility of whole\u2010body magnetization transfer (MT) contrast imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Whole\u2010body MT imaging was performed on eight healthy volunteers and five patients (mean age = 40.5 \u00b1 17.8 years) with diagnoses of dermatomyositis (<jats:italic>N<\/jats:italic> = 1), B\u2010symptoms with suspicion of paraneoplastic disease (<jats:italic>N<\/jats:italic> = 1), metastatic malignant melanoma (<jats:italic>N<\/jats:italic> = 1), and multiple sclerosis (MS) (<jats:italic>N<\/jats:italic> = 2). Measurements were carried out on a 1.5\u2010Tesla whole\u2010body MR scanner capable of parallel signal reception. A three\u2010dimensional (3D) gradient\u2010echo sequence (TR = 17 msec, TE = 4.8 msec, flip angle = 10\u00b0) was applied in combination with a Gaussian off\u2010resonance MT preparation pulse acting at an off\u2010resonance of 1.500 Hz with a 500\u00b0 effective flip angle. Whole\u2010body images were constructed from five different body regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all subjects, whole\u2010body MT contrast images were obtained within less than 20 minutes of measuring time. The images showed sufficient diagnostic image quality to assess the patients' pathologies. The MT ratios (MTRs, in percent units) for the volunteers were as follows: white matter (WM) 51.1 \u00b1 1.0, gray matter (GM) 42.2 \u00b1 1.3, skeletal muscle (mean value of four muscle groups) 50.3 \u00b1 2.1, liver 39.4 \u00b1 3.2, spleen 31.8 \u00b1 2.6, renal cortex 30.4 \u00b1 1.9, and renal medulla 25.6 \u00b1 1.3. The MTRs for the pathologies were as follows: skeletal muscle in dermatomyositis \u223c30, metastases in malignant melanoma 30.7\u201336.0, uterus myoma 49.3, and MS lesions 30\u201340.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our preliminary data indicate that MT contrast in whole\u2010body MRI is feasible, and may be useful for rapid whole\u2010body assessment of diseases that exhibit high contrast in MT imaging, such as MS and muscular disorders. J. Magn. Reson. Imaging 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20754","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T17:29:21Z","timestamp":1160414961000},"page":"1183-1187","source":"Crossref","is-referenced-by-count":29,"title":["Whole\u2010body magnetization transfer contrast imaging"],"prefix":"10.1002","volume":"24","author":[{"given":"Andreas","family":"Boss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Martirosian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"K\u00fcper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Fierlbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus D.","family":"Claussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000149250.37033.7c"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.01.019"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.4.1790967"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2432-z"},{"key":"e_1_2_5_6_2","first-page":"1041","article-title":"Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect","volume":"17","author":"Petrella JR","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050442"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880060136"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290209"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027963"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350420"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20630"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2004.08.001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02425940"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007760200093"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199903)9:3<441::AID-JMRI12>3.0.CO;2-R"},{"key":"e_1_2_5_17_2","first-page":"116","article-title":"Magnetization transfer contrast in magnetic resonance imaging","volume":"8","author":"Balaban RS","year":"1992","journal-title":"Magn Reson Q"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.683"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370610"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1061::AID-MRM10>3.0.CO;2-T"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200410000-00006"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000183947.01362.fe"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199601000-00014"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.04.028"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070204"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.20754","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.20754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:15:40Z","timestamp":1697152540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.20754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/jmri.20754"],"URL":"https:\/\/doi.org\/10.1002\/jmri.20754","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,9]]}}}